International Journal of Cell Biology

Protein Misfolding and Neurodegenerative Diseases


Publishing date
04 Oct 2013
Status
Published
Submission deadline
17 May 2013

1Laboratory of Molecular and Cellular Neurobiology, IRCCS San Raffaele Pisana, Via di Val Cannuta, 24700166 Rome, Italy

2Laboratory of Prion Neurobiology, Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Via G. La Masa, 19 20156 Milan, Italy

3Department of Chemical Engineering, Arizona State University, P.O. Box 876106, Tempe, AZ 85287-6106, USA


Protein Misfolding and Neurodegenerative Diseases

Description

Neurodegenerative diseases are a wide class of hereditary and sporadic conditions characterized by progressive nervous system dysfunction. In many neurodegenerative diseases, the critical event associated with neurodegeneration is the misfolding of a cellular protein from its native conformation to a pathological species and its accumulation as intracellular or extracellular aggregates. These disorders, commonly referred to as misfolding diseases, include Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and prion diseases and are caused by a combination of genetic and environmental factors. Spontaneous events can destabilize a misfolding-prone protein or impair the clearance mechanisms, leading to the accumulation of misfolded aggregates. Recently, evidence is emerging that selected misfolded protein species associated with neurodegenerative disorders, such as AD, PD, and frontotemporal dementia (FTD), are able to propagate their misfolding through a prion-like mechanism. These new aspects have important implications for the development of new therapeutic strategies.

We invite authors to submit original research articles as well as review articles that will contribute to and stimulate our knowledge of the mechanisms underlying protein misfolding and the understanding of the molecular and cellular basis of neurodegenerative diseases. Potential topics include, but are not limited to:

  • Role of misfolded conformers in neurodegenerative diseases
  • Formation and toxicity mechanisms of misfolded conformers
  • Development of biochemical and biophysical techniques for the analysis of aggregated proteins in vivo
  • Prion-like mechanisms in neurodegenerative diseases and therapeutic implications
  • Natural and transgenic animal models for studying neurodegenerative disorders
  • Molecular therapies for treatment of misfolding diseases
  • Development and refinement of novel delivery systems (viral and nonviral) for targeting of pathological misfolded proteins

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ijcb/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/ijcb/pmn/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2014
  • - Article ID 217371
  • - Editorial

Protein Misfolding and Neurodegenerative Diseases

Alessio Cardinale | Roberto Chiesa | Michael Sierks
  • Special Issue
  • - Volume 2014
  • - Article ID 428764
  • - Review Article

S-Nitrosation and Ubiquitin-Proteasome System Interplay in Neuromuscular Disorders

Salvatore Rizza | Costanza Montagna | ... | Giuseppe Filomeni
  • Special Issue
  • - Volume 2013
  • - Article ID 910314
  • - Review Article

Prion Protein Misfolding, Strains, and Neurotoxicity: An Update from Studies on Mammalian Prions

Ilaria Poggiolini | Daniela Saverioni | Piero Parchi
  • Special Issue
  • - Volume 2013
  • - Article ID 560421
  • - Research Article

Early Delivery of Misfolded PrP from ER to Lysosomes by Autophagy

Constanza J. Cortes | Kefeng Qin | ... | James A. Mastrianni
  • Special Issue
  • - Volume 2013
  • - Article ID 543803
  • - Review Article

Synaptic Dysfunction in Prion Diseases: A Trafficking Problem?

Assunta Senatore | Elena Restelli | Roberto Chiesa
  • Special Issue
  • - Volume 2013
  • - Article ID 638083
  • - Review Article

Role of Protein Misfolding and Proteostasis Deficiency in Protein Misfolding Diseases and Aging

Karina Cuanalo-Contreras | Abhisek Mukherjee | Claudio Soto
  • Special Issue
  • - Volume 2013
  • - Article ID 674751
  • - Review Article

ER Dysfunction and Protein Folding Stress in ALS

Soledad Matus | Vicente Valenzuela | ... | Claudio Hetz
  • Special Issue
  • - Volume 2013
  • - Article ID 150952
  • - Review Article

Small-Molecule Theranostic Probes: A Promising Future in Neurodegenerative Diseases

Suzana Aulić | Maria Laura Bolognesi | Giuseppe Legname
  • Special Issue
  • - Volume 2013
  • - Article ID 141083
  • - Review Article

Convergence of Synapses, Endosomes, and Prions in the Biology of Neurodegenerative Diseases

Gunnar K. Gouras
  • Special Issue
  • - Volume 2013
  • - Article ID 704546
  • - Review Article

Prions Ex Vivo: What Cell Culture Models Tell Us about Infectious Proteins

Sybille Krauss | Ina Vorberg
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