Table of Contents
International Journal of Carbohydrate Chemistry
Volume 2009, Article ID 305276, 9 pages
Research Article

Convenient Approach to Access Octa-Glycosylated Porphyrins via “Click Chemistry”

1Department of Life Sciences, Toyo University, 1-1-1 Izumino, Itakura-machi, Ora-gun, Gunma 374-0193, Japan
2Bio-Nano Electronics Research Centre, Toyo University, 2100 Kujirai, Kawagoe, Saitama 350-8585, Japan

Received 9 June 2009; Revised 12 August 2009; Accepted 4 September 2009

Academic Editor: Yuan Chuan Lee

Copyright © 2009 Misako Okada et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Easy, quantitative, and one-pot introduction of eight -lactoside-modules onto a porphyrin-core was achieved through -catalyzed chemoselective coupling (click chemistry) between a porphyrin carrying eight alkyne-terminals and -lactosyl azides. The obtained porphyrin-based glycocluster shows not only good water-solubility but also strong/specific lectin-affinity.