Table of Contents
International Journal of Carbohydrate Chemistry
Volume 2013, Article ID 320892, 5 pages
Research Article

Synthesis and Antimicrobial Activity of Carbohydrate Based Schiff Bases: Importance of Sugar Moiety

1Campus São Gabriel, Universidade Federal do Pampa, Avenida Antônio Trilha 1847, 97300-000 São Gabriel, RS, Brazil
2Campus Cerro Largo, Universidade Federal da Fronteira Sul, R. Major Antônio Cardoso 590, 97900-000 Cerro Largo, RS, Brazil
3Ciências da Saúde, Centro Universitário Franciscano, Rua dos Andradas 1614-Centro, -97010-032 Santa Maria, RS, Brazil
4Departamento de Química, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil

Received 25 September 2013; Revised 12 November 2013; Accepted 14 November 2013

Academic Editor: J. F. Vliegenthart

Copyright © 2013 Helmoz R. Appelt et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A series of D-glucosamine derivatives were synthesized (2–4) and evaluated for their antimicrobial activity. Some of the compounds investigated have shown significant antimicrobial activity against Gram-positive and Gram-negative bacterial strains as well as a few fungal strains. The results suggest that the presence of sugar moiety is necessary to biological activity.