Thio-β-D-glucosides: Synthesis and Evaluation as Glycosidase Inhibitors and Activators

Table 1

Inhibition of β-D-glucosidases at pH 4.2 and 30°C.

Inhibitor (R)	-D-Glucosidase	-D-Glucosidase
	A. oryzae	P. canescens
	, μM	, μM
2a (Ph)^a	129	4.02
2b (p-ClC6H4)	183	5.56
2c (p-MeC6H4)	218	11.1
2d (2′-naphthyl)	159	4.53
2e (PhCH2)	109	6.32
2f (n-C6H13)	80.7	3.45
2g (5′-phen)	91.7	2.84
2h (diester)	223	12.3
2i (diacid)	1500	27.5

= 1530 μM (for -D-glucosidase from fungus Stachybotrys atra) [21].