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International Journal of Chronic Diseases
Volume 2015, Article ID 152616, 6 pages
Research Article

Mean Platelet Volume and Splenomegaly as Useful Markers of Subclinical Activity in Egyptian Children with Familial Mediterranean Fever: A Cross-Sectional Study

1Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo 11562, Egypt
2Department of Medical Biochemistry, Faculty of Medicine, Cairo University, Cairo 11562, Egypt
3Department of Rheumatology, Faculty of Medicine, Cairo University, Cairo 11562, Egypt

Received 8 June 2015; Revised 27 June 2015; Accepted 5 July 2015

Academic Editor: Sulaiman M. Al-Mayouf

Copyright © 2015 Huda Marzouk et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To study whether mean platelet volume (MPV) and splenomegaly could be used as subclinical inflammatory markers in children with familial Mediterranean fever (FMF) at the attack-free period. Patients and Methods. The study included ninety-seven children with FMF. MPV was carried out within 4 hours of blood sampling according to standard laboratory practice. Splenomegaly was determined by abdominal ultrasound (USG). Results. High MPV was detected in 84.45% of our studied patients and was significantly higher in FMF patients with splenomegaly than in patients without splenomegaly. There was a statistically significant correlation between MPV and splenic span (). Conclusion. Elevated MPV and its significant correlation with splenic span in FMF children during the attack-free periods support the use of MPV and splenomegaly as useful markers of the subclinical inflammation in FMF patients at the attack-free period.