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International Journal of Chronic Diseases
Volume 2015, Article ID 680104, 8 pages
Review Article

Does Intensive Glucose Control Prevent Cognitive Decline in Diabetes? A Meta-Analysis

1Universidad Catolica de Santiago de Guayaquil, 090112 Guayas, Ecuador
2Miller School of Medicine, University of Miami, Miami, FL 33136, USA

Received 27 June 2015; Accepted 16 July 2015

Academic Editor: Katarzyna Zorena

Copyright © 2015 Carlos Peñaherrera-Oviedo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Diabetes mellitus is associated with cognitive decline and impaired performance in cognitive function tests among type 1 and type 2 diabetics. Even though the use of tight glucose control has been limited by a reported higher mortality, few reports have assessed the impact of treatment intensity on cognitive function. We conducted a meta-analysis to evaluate if an intensive glucose control in diabetes improves cognitive function, in comparison to standard therapy. We included 7 studies that included type 1 or type 2 diabetics and used standardized tests to evaluate various cognitive function domains. Standardized mean differences (SMDs) were calculated for each domain. We found that type 1 diabetics get no cognitive benefit from a tight glucose control, whereas type 2 diabetics get some benefit on processing speed and executive domains but had worse performances in the memory and attention domains, along with a higher incidence of mortality when using intensive glucose control regimes.