Review Article

Does Intensive Glucose Control Prevent Cognitive Decline in Diabetes? A Meta-Analysis

Table 3

Mean (SD) results from each cognitive function test utilized in the studies included.

Study DM type DSST (number of correct pairings in 50 seconds) Trail Making Test (seconds) Similarities subtest of WAIS (age-adjusted score 0–19) Visual reaction time (milliseconds) Auditory reaction time (milliseconds) RAVLT (number of freely recalled words) Stroop test (number of correct items in 45 seconds) Finger tap for dominant hand (taps in 10 seconds) Finger tap for nondominant hand (taps in 10 seconds)
ICICICICICICICICIC

Reichard et al. [13]139.945.62412412092076.86.56.26.1

DCCT [14]164.7 (11.3)64.8 (11.2)52.9 (16.7)53.5 (19.6)12.5 (2.4)12.6 (2.3)15.4 (1.7)15.3 (1.9)4.9 (0.7)4.9 (0.7)4.4 (0.6)4.5 (0.6)

EDIC [15]162.3 (11.4)61.9 (11.4)54.4 (20)55 (18.8)14 (2.2)13.9 (2.3)14.7 (2.2)15 (2)5.1 (0.7)5.1 (0.8)4.5 (0.7)4.5 (0.7)

Musen et al. [16]167.8 (10.5)66.3 (9.1)45.6 (12.8)48.9 (15.1)13.8 (2.2)13.1 (2.4)15.5 (1.4)15.3 (1.7)5.2 (0.7)5.1 (0.7)4.7 (0.6)4.5 (0.7)

Naor et al. [17]293.8 (17.1)140 (35.6)284.7 (22.8)309.1 (54.7)211.4 (42.8)218.1 (38.1)

Launer et al. [18]250.93 (0.43)50.61 (0.42)7.98 (0.1)7.99 (0.09)31.45 (0.36)32.06 (0.36)

Koekkoek et al. [19]255.6 (17.4)57 (15.5)93.5 (39.4)96.5 (50.2)8.3 (3.5)8.1 (3)8.3 (3.5)8.1 (3)50.2 (8.4)50.1 (11.6)

Standard deviation (SD) not reported.
I: intensive glucose control group.
C: conventional therapy group.
“—” denotes that such test was not carried out in the corresponding study.