Female Sex Hormones Pattern and Its Relation to Disease Severity and Treatment in Pre- and Postmenopausal Patients with Chronic Hepatitis C Virus (Genotype 4) Infection
Table 1
Demographic, clinical, biochemical, and histopathological data of patients and healthy controls.
Variables
Controls (RA)
Cases (RA)
Controls (M)
Cases (M)
22
22
22
22
Age (yrs)
34.32 ± 8.39
38.27 ± 7.38
57.09 ± 3.73
55.32 ± 3.80
BMI (kg/m2)
24.45 ± 3.17
25.14 ± 3.63
27.45 ± 3.23
26.27 ± 3.31
AAM (yrs)
11.41 ± 1.50
12.18 ± 1.62
11.41 ± 1.84
11.18 ± 1.74
Married (%)
14 (63.6%)
18 (81.1%)
21 (95.4%)
21 (95.4%)
Parity
2.29 ± 1.27
2.78 ± 1.11
3.33 ± 1.39
3.38 ± 1.20
DM (%)
3 (13.6%)
3 (13.6%)
10 (45.5%)
7 (31.8%)
HTN (%)
3 (13.6%)
5 (22.7%)
9 (40.9%)
10 (45.5%)
Hemoglobin (12–16 g/dL)
12.43 ± 0.96
12.6 ± 1.2
12.37 ± 1.05
12.52 ± 1.47
TLC (4.000–11.000/mm3)
7543.63 ± 2432.9
7081.82 ± 2194.56
7140.45 ± 2241.4
6215.0 ± 2279.34
Platelets (150.000–400.000/mm3)
233000 ± 66960.5
214954.5 ± 86489.46
226136.4 ± 59978.8
154818.2 ± 46953.5
ALT (40) IU/L
23.68 ± 5.07
51.99 ± 31.93
24.4 ± 3.87
57.86 ± 29.3
AST (40) IU/L
23.18 ± 4.97
48.6 ± 19.87
25 ± 3.48
61.90 ± 27.8
Bilirubin (0–2 mg/dL)
0.63 ± 0.32
0.563 ± 0.22
0.66 ± 0.28
0.66 ± 0.25
Albumin (3.5–5 g/dL)
3.96 ± 0.24
3.9 ± 0.49
3.87 ± 0.28
3.56 ± 0.58
INR (0.9–1.1)
0.95 ± 0.2
1.09 ± 0.12
0.91 ± 0.27
1.26 ± 0.24
AFP (10 ng/dL)
—
3.56 ± 3.04
—
5.56 ± 3.7
HCV RNA (IU/mL) baseline before treatment
—
577340 ± 293440
—
587400 ± 230269
Histological parameters
≤F2 number (%)
—
16 (72.7%)
—
9 (40.9%)
>F2 number (%)
—
6 (27.3%)
—
13 (59.1%)
<A2 number (%)
—
11 (50%)
—
8 (36.4%)
≥A2 number (%)
—
11 (50%)
—
14 (63.6%)
Response to treatment
Responders number (%)
—
17 (77.3%)
—
9 (40.9%)
Nonresponders number (%)
—
3 (13.6%)
—
12 (54.4%)
Relapsers number (%)
—
2 (9.1%)
—
1 (4.5%)
Hormonal levels
E2 (pg/mL)
106.5 ± 50.85
120.0 ± 56.74
20.43 ± 2.12
94.91 ± 46.82
TT (ng/dL)
19.9 ± 0.85
20.51 ± 2.88
19.97 ± 1.02
31.6 ± 13.0
PRG (ng/mL)
1.15 ± 0.76
1.21 ± 0.76
0.30 ± 0.133
0.60 ± 0.32
A, activity; AAM, age at menarche; ALT, alanine aminotransferase; AFP, alpha fetoprotein; AST, aspartate aminotransferase; BMI, body mass index; DM, diabetes mellitus; E2, estradiol; F, fibrosis; HTN, hypertension; INR, International Normalized Ratio; M, menopausal group; , number of individuals; PRG, progesterone; RA, reproductive age group; TLC, total leucocytic count; TT, total testosterone. -test: statistically significant difference between corresponding controls and cases groups “menopausal or reproductive aged women”; statistically significant difference between control group reproductive aged women and menopausal women; statistically significant difference between HCV infected group reproductive aged women and menopausal women.
