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International Journal of Chronic Diseases
Volume 2018, Article ID 1296717, 7 pages
https://doi.org/10.1155/2018/1296717
Research Article

Efficacy and Safety of Daikenchuto for Constipation and Dose-Dependent Differences in Clinical Effects

1Department of Pharmacy, Ogaki Municipal Hospital, 4-86 Minaminokawa-cho, Ogaki-shi, Gifu 503-8502, Japan
2Laboratory of Pharmacy Practice and Social Science, Gifu Pharmaceutical University, 1-25-4 Daigagu-nishi, Gifu-shi 501-1196, Japan

Correspondence should be addressed to Tatsuya Hirose; moc.liamg@7280nonak.h

Received 13 November 2017; Revised 23 January 2018; Accepted 31 January 2018; Published 5 March 2018

Academic Editor: Katarzyna Zorena

Copyright © 2018 Tatsuya Hirose et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Tamura, T. Tomita, T. Oshima et al., “Prevalence and self-recognition of chronic constipation: Results of an internet survey,” Journal of Neurogastroenterology and Motility, vol. 22, no. 4, pp. 677–685, 2016. View at Publisher · View at Google Scholar · View at Scopus
  2. N. C. Suares and A. C. Ford, “Prevalence of, and risk factors for, chronic idiopathic constipation in the community: systematic review and meta-analysis,” American Journal of Gastroenterology, vol. 106, no. 9, pp. 1582–1591, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. W. F. Stewart, J. N. Liberman, R. S. Sandler et al., “Epidemiology of constipation (EPOC) study in the United States: relation of clinical subtypes to sociodemographic features,” American Journal of Gastroenterology, vol. 94, no. 12, pp. 3530–3540, 1999. View at Publisher · View at Google Scholar · View at Scopus
  4. D. Nellesen, K. Yee, A. Chawla, B. E. Lewis, and R. T. Carson, “A systematic review of the economic and humanistic burden of illness in irritable bowel syndrome and chronic constipation,” Journal of Managed Care Pharmacy, vol. 19, no. 9, pp. 755–764, 2013. View at Publisher · View at Google Scholar · View at Scopus
  5. K. Winge, D. Rasmussen, and L. M. Werdelin, “Constipation in neurological diseases,” Journal of Neurology, Neurosurgery & Psychiatry, vol. 74, no. 1, pp. 13–19, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. M. A. Daulatzai, “Chronic functional bowel syndrome enhances gut-brain axis dysfunction, neuroinflammation, cognitive impairment, and vulnerability to dementia,” Neurochemical Research, vol. 39, no. 4, pp. 624–644, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. G. Lindberg, S. S. Hamid, P. Malfertheiner et al., “World Gastroenterology Organisation global guideline: constipation—a global perspective,” Journal of Clinical Gastroenterology, vol. 45, no. 6, pp. 483–487, 2011. View at Publisher · View at Google Scholar
  8. P. Gallagher and D. O'Mahony, “Constipation in old age,” Best Practice & Research Clinical Gastroenterology, vol. 23, no. 6, pp. 875–887, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. H. Suzuki, J. M. Inadomi, and T. Hibi, “Japanese herbal medicine in functional gastrointestinal disorders,” Neurogastroenterology & Motility, vol. 21, no. 7, pp. 688–696, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. S. Yakubo, M. Ito, Y. Ueda et al., “Pattern classification in Kampo medicine,” Evidence-Based Complementary and Alternative Medicine, vol. 2014, Article ID 535146, 5 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. Sato, F. Katagiri, S. Inoue, H. Itoh, and M. Takeyama, “Dai-kenchu-to raises levels of calcitonin gene-related peptide and substance P in human plasma,” Biological & Pharmaceutical Bulletin, vol. 27, no. 11, pp. 1875–1877, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. E. Mochiki, M. Yanai, T. Ohno, and H. Kuwano, “The effect of traditional Japanese medicine (Kampo) on gastrointestinal function,” Surgery Today, vol. 40, no. 12, pp. 1105–1111, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. T. Kono, M. Shimada, M. Yamamoto et al., “Complementary and synergistic therapeutic effects of compounds found in Kampo medicine: Analysis of daikenchuto,” Frontiers in Pharmacology, vol. 6, article no. 159, 2015. View at Publisher · View at Google Scholar · View at Scopus
  14. N. Iizuka and Y. Hamamoto, “Constipation and herbal medicine,” Frontiers in Pharmacology, vol. 6, article 73, 2015. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Yuki, Y. Komazawa, Y. Kobayashi et al., “Effects of Daikenchuto on Abdominal Bloating Accompanied by Chronic Constipation: A Prospective, Single-Center Randomized Open Trial,” Current Therapeutic Research - Clinical and Experimental, vol. 77, pp. 58–62, 2015. View at Publisher · View at Google Scholar · View at Scopus
  16. K. S. Coyne, J.-L. Poon, C. Thompson, Y. Hu, C. J. Datto, and M. Sostek, “Translating Clinical Findings into the Patient's Perspective: Post-hoc Pooled Analysis of Bowel Movement Changes as a Predictor of Improvement in Patients’ Opioid-induced Constipation Symptoms and Outcomes,” Clinical Therapeutics, vol. 39, no. 1, pp. 75–88, 2017. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Guérin, R. Mody, B. Fok et al., “Risk of developing colorectal cancer and benign colorectal neoplasm in patients with chronic constipation,” Alimentary Pharmacology & Therapeutics, vol. 40, no. 1, pp. 83–92, 2014. View at Publisher · View at Google Scholar · View at Scopus
  18. B. R. Collins and L. O'Brien, “Prevention and management of constipation in adults,” Nursing standard, vol. 29, no. 32, pp. 49–58, 2015. View at Publisher · View at Google Scholar · View at Scopus
  19. R. Sakakibara, T. Odaka, Z. Lui et al., “Dietary herb extract dai-kenchu-to ameliorates constipation in parkinsonian patients (Parkinson's disease and multiple system atrophy) [3],” Movement Disorders, vol. 20, no. 2, pp. 261-262, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. H. Tsuda, T. Kotani, S. Sumigama, Y. Mano, H. Hayakawa, and F. Kikkawa, “Efficacy and safety of daikenchuto (TJ-100) in pregnant women with constipation,” Taiwanese Journal of Obstetrics and Gynecology, vol. 55, no. 1, pp. 26–29, 2016. View at Publisher · View at Google Scholar · View at Scopus
  21. T. Numata, S. Takayama, M. Tobita et al., “Traditional Japanese medicine Daikenchuto improves functional constipation in poststroke patients,” Evidence-Based Complementary and Alternative Medicine, vol. 2014, Article ID 231258, 8 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  22. J. Iturrino, M. Camilleri, B. S. Wong, S. J. Linker Nord, D. Burton, and A. R. Zinsmeister, “Randomised clinical trial: The effects of daikenchuto, TU-100, on gastrointestinal and colonic transit, anorectal and bowel function in female patients with functional constipation,” Alimentary Pharmacology & Therapeutics, vol. 37, no. 8, pp. 776–785, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. T. Nagano, H. Itoh, and M. Takeyama, “Effect of Dai-kenchu-to on levels of 3 brain-gut peptides (motilin, gastrin and somatostatin) in human plasma,” Biological and Pharmaceutical Bulletin, vol. 22, pp. 1131–1133, 1999. View at Google Scholar
  24. D. Kikuchi, C. Shibata, H. Imoto, T. Naitoh, K. Miura, and M. Unno, “Intragastric Dai-Kenchu-To, a Japanese herbal medicine, stimulates colonic motility via transient receptor potential cation channel subfamily V member 1 in dogs,” The Tohoku Journal of Experimental Medicine, vol. 230, no. 4, pp. 197–204, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. T. Kono, A. Kaneko, Y. Omiya, K. Ohbuchi, N. Ohno, and M. Yamamoto, “Epithelial transient receptor potential ankyrin 1 (TRPA1)-dependent adrenomedullin upregulates blood flow in rat small intestine,” American Journal of Physiology-Gastrointestinal and Liver Physiology, vol. 304, no. 4, pp. G428–G436, 2013. View at Publisher · View at Google Scholar · View at Scopus
  26. K. Kubota, N. Ohtake, K. Ohbuchi et al., “Hydroxy-α sanshool induces colonic motor activity in rat proximal colon: A possible involvement of KCNK9,” American Journal of Physiology-Gastrointestinal and Liver Physiology, vol. 308, no. 7, pp. G579–G590, 2015. View at Publisher · View at Google Scholar · View at Scopus
  27. K. Satoh, K. Hashimoto, T. Hayakawa et al., “Mechanism of atropine-resistant contraction induced by Dai-kenchu-to in guinea pig ileum,” Japanese Journal of Pharmacology, vol. 86, no. 1, pp. 32–37, 2001. View at Publisher · View at Google Scholar · View at Scopus
  28. N. Manabe, M. Camilleri, A. Rao et al., “Effect of daikenchuto (TU-100) on gastrointestinal and colonic transit in humans,” American Journal of Physiology-Gastrointestinal and Liver Physiology, vol. 298, no. 6, pp. G970–G975, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. A. Shavakhi, M. Kianinia, G. Torabi et al., “High dose Senna or poly ethylene glycol (PEG) for elective colonoscopy preparation: A prospective randomized investigator-blinded clinical trial,” Journal of Research in Medical Sciences, vol. 16, no. 2, pp. 149–155, 2011. View at Google Scholar · View at Scopus
  30. H. A. Spiller, M. L. Winter, J. A. Weber, E. P. Krenzelok, D. L. Anderson, and M. L. Ryan, “Skin breakdown and blisters from senna-containing laxatives in young children,” Annals of Pharmacotherapy, vol. 37, no. 5, pp. 636–639, 2003. View at Publisher · View at Google Scholar · View at Scopus