Tenofovir-Based Highly Active Antiretroviral Therapy Is Associated with Superior CD4 T Cells Repopulation Compared to Zidovudine-Based HAART in HIV 1 Infected Adults

Table 2

Comparison of CD4 T cells count change between treatment groups and how other variables affect CD4 T cells reconstitution following the initiation of HAART.

Comparison between baseline CD4 count and outcome after median of 5 months after HAART
Group	Pretreatment cells/µL	Posttreatment cells/µL		value
Overall	142.5 ( 0–556)	327 (45–972)		<0.0001
ZLE	104 (0–509)	200 (45–889)		<0.0001
TLE	150 (3–556)	337 (69–972)		<0.0001
Determination of the effect HIV co-morbidities, gender, and increasing age on with CD4 T cell reconstitution
Parameter				value
	Gender
CD4+ count change after 5 months of TLE/ZLE treatment	Male	Female
	149.7 (21–401)	217 (7–516)		0.0094
	Age group (years)
	20 to 40	>40
	364.5 (45–972)	352.1 (76–697)		0.3184
	TB status
	No	Yes
	190.1 (0–500)	211.9 (21–578)		0.5717
	Hepatitis B status
	No	Yes
	172 (0–578)	215.6 (52–319)		0.3059
	Treatment group
	ZLE	TLE
	109.5 (21–275)	214 (0–795)		<0.0001
Multivariate model to predict the influencing variables on CD4 change after HAART
(8, 78) = 1.03, Prob > , , adjusted
CD4 change	Coefficient	Standard error		value
Gender	−89.999	47.207	−1.91	0.060
Age	−0.313	1.758	−0.18	0.859
Hepatitis B	73.777	87.532	0.84	0.402
Tuberculosis	61.796	54.536	1.13	0.261
Baseline CD4	0.066	0.1292	0.52	0.607
Baseline Hb	15.814	11.682	1.35	0.180
Baseline CD8	−0.0123	0.015	−0.82	0.412
Herbs use	−46.145	42.435	−1.09	0.280

From the table, data is presented as median with range values. TLE: tenofovir, lamivudine, and efavirenz and ZLE: zidovudine, lamivudine, and efavirenz. is significant at 0.05. Mann–Whitney test was used to compare the median CD4 cells count increase between the tenofovir treatment group (TLE) and the zidovudine treatment group (ZLE) and likewise the effect age, gender, and comorbidities at univariate level. The last part of the table is a multivariate regression analysis to identify variables that may predict CD4 T cells count change. is the test-statistic, and is the probability of predictive value of each variable on CD4 T cells count significant at 0.05. measures the degree of correlation between variables with CD4 T cells count change.