Research Article
Hippocampal Growth Factor and Myokine Cathepsin B Expression following Aerobic and Resistance Training in 3xTg-AD Mice
Figure 5
IGF-1 expression and signaling in the hippocampus of exercise-trained 3xTg-AD mice. (a) Representative immunoblots for IGF-1R and MAPK. (b) IGF-1 concentration in hippocampal homogenate measured by ELISA. (c) p-IGF-1R normalized to total IGF-1R. (d) p-MAPK normalized to MAPK. (e) Representative immunoblots for Akt and GSK3β. (f) p-Akt normalized to Akt. (g) p-GSK3β normalized to total GSK3β. Data presented as . Tissues assayed from the nonexercised group (Tg), the aerobic-trained group (Tg+AT), or the resistance-trained group (Tg+RT) (/group). Differences determined by one-way ANOVA. and .
(a) |
(b) |
(c) |
(d) |
(e) |
(f) |
(g) |