Peptide-Loaded Solid Lipid Nanoparticles Prepared through Coacervation Technique

Table 1

SLN composition, mean diameter, and EE%.

	1 : 1 Leuprolide AOT				1 : 2 Leuprolide AOT		Insulin-loaded
	loaded 1% SLN				loaded 1% SLN		2% SLN
	1%	0.25%	0.5%	0.5%	0.5%	0.5%	2%
	PVA9000	PVA9000	PVA9000	PVA85000	PVA9000	PVA85000	PVA9000
SS (mg)	107*	107*	107*	107*	107*	107*	215**
PVA9000 (mg)	100	25	50		50		200
PVA120000 (mg)				50		50
Leuprolide (mg)	5	5	5	5	5	5
Insulin (mg)							5
AOT (mg)	1.55	1.55	1.55	1.55	3.1	3.1
SDS (mg)							1.5
1 M lactic acid (mL)	0.5	0.5	0.5	0.5	0.5	0.5	1
Water (mL)	9.5	9.5	9.5	9.5	9.5	9.5	9.0
Mean size (nm)	320  ±  30	522  ±  45	377  ±  36	338  ±  29	390  ±  45	350  ±  30	418  ±  39
polydispersity	0.050	0.260	0.224	0.048	0.201	0.060	0.055
EE%	48.5  ±  1.0	50.4  ±  2.1	52.6  ±  2.6	53.9  ±  1.2	80.4  ±  2.5	86.8  ±  4.0	89.0  ±  2.0

*corresponding to 100 mg SA.
**corresponding to 200 mg SA.