Research Article

Hybrid Anion Exchange Hollow Fiber Membrane for Delivery of Ionic Drugs

Table 1

Structures and physicochemical characteristics of the model drugs.

CompoundStructureMwpKa17–20HBD/HBA*

Sodium benzoate (NaBS)832190.fig.008a144.14.17 (–COOH)0/2
Sodium salicylate (NaSA)832190.fig.008b160.12.98 (–COOH), 13.9 (–OH)1/3
Sodium meta-amino salicylate (NaMAS)832190.fig.008c175.12.74 (–COOH), 5.84 (– ), 13.9 (–OH)1/4
Loxoprofen sodium (NaLS)832190.fig.008d268.34.20 (–COOH)0/3

*Hydrogen bond donor (based on –OH groups)/hydrogen bond acceptor (based on O-atoms and N-atoms); it is assumed that carboxyl groups are ionized during the experiments.