NUTRIC Score Is Not Superior to mNUTRIC Score in Prediction of Mortality of COVID-19 Patients
Table 4
Comparisons of the patient data in respect of the NUTRIC and mNUTRIC scores.
NUTRIC score
Modified NUTRIC score
Low n = 260
High n = 62
value
Low n = 236
High n = 86
value
Age (years) (min–max)
67 (19–92)
80 (40–99)
0.0001
66 (19–92)
80 (36–99)
0.0001
Gender
Male, n (%)
164 (63.1)
36 (58.1)
0.470
150 (63.6)
50 (58.1)
0.436
Female, n (%)
96 (36.9)
26 (41.9)
86 (36.4)
36 (41.9)
Comorbidities
Diabetes mellitus, n (%)
107 (41.2)
20 (32.3)
0.247
98 (41.5)
29 (33.7)
0.246
Hypertension, n (%)
159 (61.2)
44 (71.0)
0.188
142 (60.2)
61 (70.9)
0.090
Coronary artery disease, n (%)
71 (27.3)
23 (37.1)
0.161
62 (26.3)
32 (37.2)
0.071
Heart failure, n (%)
15 (5.8)
9 (14.5)
0.029
12 (5.1)
12 (14.0)
0.014
Arrhythmia, n (%)
12 (4.6)
6 (9.7)
0.128
8 (3.4)
10 (11.6)
0.010
Chronic obstructive pulmonary disease, n (%)
30 (11.5)
10 (16.1)
0.390
24 (10.2)
16 (18.6)
0.055
Asthma, n (%)
16 (6.2)
3 (4.8)
1.000
14 (5.9)
5 (5.8)
1.000
Renal failure, n (%)
12 (4.6)
17 (27.4)
0.0001
9 (3.8)
20 (23.3)
0.0001
Malignancy, n (%)
17 (6.5)
7 (11.3)
0.278
15 (6.4)
9 (10.5)
0.233
History of cerebrovascular event, n (%)
14 (5.4)
9 (14.5)
0.024
10 (4.2)
13 (15.1)
0.024
Alzheimer’s disease, n (%)
21 (8.1)
10 (16.1)
0.089
16 (6.8)
15 (17.4)
0.009
Parkinson’s disease, n (%)
2 (0.8)
1 (1.6)
0.475
1 (0.4)
2 (2.3)
0.175
Liver disease, n (%)
3 (1.2)
1 (1.6)
0.577
3 (1.3)
1 (1.2)
1.000
Anxiety/panic disorder, n (%)
6 (2.3)
3 (4.8)
0.382
5 (2.1)
4 (4.7)
0.255
Others, n (%)
17 (6.5)
2 (3.2)
0.547
17 (7.2)
2 (2.3)
0.115
Length of stay in ICU (days) (median) (min–max)
10 (2–41)
6 (2–43)
0.036
10 (2–41)
7 (2–43)
0.142
Length of stay in hospital before admittance to ICU (days) (median) (min–max)
2 (0–18)
2 (0–24)
0.091
2 (0–18)
2 (0–24)
0.148
Total length of hospital stay (days) (median) (min–max)
15 (2–69)
10 (2–46)
0.001
15 (2–69)
11 (2–46)
0.0001
Glasgow Coma Scale (median) (min–max)
15 (3–15)
7 (3–15)
0.0001
15 (6–15)
10 (3–15)
0.0001
Apache II (median) (min–max)
10 (2–34)
22 (3–39)
0.0001
9 (2–26)
21 (3–39)
0.0001
SOFA score (median) (min–max)
2 (1–9)
10 (4–16)
0.0001
2 (1–7)
9 (2–16)
0.0001
Patient outcome
Survival, n (%)
136 (52.3)
1 (1.6)
0.0001
133 (56.4)
4 (4.7)
0.0001
Exitus, n (%)
124 (47.7)
61 (98.4)
103 (43.6)
82 (95.3)
Severity according to CDC
Severe pneumonia, n (%)
246 (94.6)
9 (14.5)
0.0001
227 (96.2)
28 (32.6)
0.0001
Critical disease, n (%)
14 (5.4)
53 (85.5)
9 (3.8)
58 (67.4)
Nasal cannula/mask requirement, n (%)
255 (98.1)
26 (41.9)
0.0001
233 (98.7)
48 (55.8)
0.0001
High-flow nasal oxygen requirement, n (%)
199 (76.5)
24 (38.7)
0.0001
179 (75.8)
44 (51.2)
0.0001
Noninvasive mechanical ventilator requirement, n (%)
67 (25.8)
6 (9.7)
0.006
62 (26.3)
11 (12.8)
0.010
Invasive mechanical ventilator requirement, n (%)
127 (48.8)
62 (100.0)
0.0001
106 (44.9)
83 (96.5)
0.0001
Use of vasopressors on admittance to ICU, n (%)
14 (5.4)
53 (85.5)
0.0001
9 (3.8)
58 (67.4)
0.0001
Requirement for vasopressors in ICU, n (%)
85 (32.7)
60 (96.8)
0.0001
69 (29.2)
76 (88.4)
0.0001
Acute kidney injury, n (%)
58 (22.3)
47 (75.8)
0.0001
47 (19.9)
58 (67.4)
0.0001
Requirement for dialysis and/or CRRT, n (%)
38 (14.6)
33 (53.2)
0.0001
32 (13.6)
39 (45.3)
0.0001
Creatinine, mg/dL (median) (min–max)
0.89 (0.27–18.1)
2.22 (0.57–8.42)
0.0001
0.88 (0.27–7.41)
1.72 (0.47–18.1)
0.0001
Albumin, g/dL (median) (min–max)
3.5 (1.5–4.5)
3.2 (2.1–4.2)
0.0001
3.5 (1.5–4.5)
3.3 (2.1–4.2)
0.0001
Total bilirubin, µmol/L (median) (min–max)
0.6 (0.1–2.7)
0.6 (0.1–17.6)
0.029
0.6 (0.1–2.7)
0.6 (0.1–17.6)
0.152
D-Dimer, µg/mL (median) (min–max)
1.51 (0.19–80.0)
3.75 (0.6–35.2)
0.055
1.49 (0.19–70.9)
2.97 (0.2–80.0)
0.027
Procalcitonin, ng/ml (median (min–max)
0.19 (0.02–202.9)
0.95 (0.03–511.4)
0.001
0.18 (0.02–202.9)
0.68 (0.03–511.4)
0.009
Ferritin, ng/mL (median) (min–max)
597 (14–42079
867 (55–21309)
0.0001
600 (14–4207)
782 (55–21309)
0.0001
WBC, 10³/µL (median) (min–max)
8.6 (1.53–26.8)
13.4 (0.12–39.5)
0.0001
8.67 (1.53–26.8)
11.3 (0.12–39.5)
0.0001
Neutrophils, 10³/µL (median) (min–max)
7.2 (1.06–456)
11.6 (0.04–26.4)
0.621
7.23 (1.06–24.9)
9.91 (0.04–456)
0.016
Lymphocytes, 10³/µL (median) (min–max)
0.65 (0.05–20.6)
0.61 (0.02–27.7)
0.031
0.66 (0.05–20.6)
0.61 (0.02–27.7)
0.146
Haemoglobin, g/dL (median) (min–max)
13.1 (6.1–17.2)
12.1 (5.8–16.9)
0.0001
13.2 (6.1–17.2)
12.1 (5.8–16.9)
0.0001
Thrombocytes, 10³/µL (median) (min–max)
252 (34–767)
227 (23–613)
0.205
252 (64–767)
235 (23–613)
0.041
Neutrophil/Lymphocyte ratio (median) (min–max)
10.4 (0.14–165.2)
15.9 (0.13–70.6)
0.010
10.3 (0.14–165.2)
14.2 (0.13–70.6)
0.023
Lactate, mmol/L (median) (min–max)
2.07 (0.5–6.9)
2.38 (0.67–7.1)
0.031
2.08 (0.55–6.95)
2.31 (0.59–7.07)
0.113
IL-6, pg/ml (median) (min–max)
49 (2–1492)
124 (9.4–2150)
0.0001
48.9 (2.1–1492)
91.6 (2–2150)
0.001
CRP, mg/L (median) (min–max)
133 (1–335)
148 (1–373)
0.273
133 (1–335)
141 (1–373)
0.489
APACHE II, Acute Physiology and Chronic Health Evaluation II; SOFA, Sequential Organ Function Assessment; WBC: white blood cell; CRP, C-reactive protein; IL-6, interleukin-6; ICU, Intensive Care Unit. value < 0.05 is statistically significant.
