Effect of Glucocorticoid Administration in Intravenous Pulses on Selected Parameters of the Coagulation System
Table 3
Comparison of changes in coagulation system parameters after 3 g methylprednisolone administration with the baseline values in the study group (N = 48)∗.
Variable
Mean/median
Baseline
After 3 g
Measures
Measures
%∗∗
P∗∗∗
Factor VIII
Mean (SD)
118.73 (26.94)
170.06 (40.97)
+43.23%
<0.001
Median (Q1–Q3)
115.50 (98.50–132.00)
166.00 (147.00–197.00)
+43.72%
<0.001
Factor IX
Mean (SD)
115.73 (14.67)
143.35 (35.85)
+23.87%
<0.001
Median (Q1–Q3)
114.50 (106.00–122.50)
139.50 (128.00–147.00)
+21.83%
<0.001
Factor XI
Mean (SD)
109.56 (16.94)
129.73 (35.98)
+18.41%
<0.001
Median (Q1–Q3)
107.50 (99.00–120.50)
122.50 (105.50–143.50)
+13.95%
<0.001
AT
Mean (SD)
103.44 (7.19)
109.44 (10.25)
+5.80%
<0.001
Median (Q1–Q3)
104.00 (98.00–108.50)
109.50 (102.00–118.50)
+5.29%
<0.001
PC act.
Mean (SD)
119.42 (17.95)
146.33 (29.49)
+22.53%
<0.001
Median (Q1–Q3)
119.50 (105.50–133.00)
139.00 (128.00–160.00)
+16.32%
<0.001
PS act.
Mean (SD)
82.42 (21.65)
85.48 (22.45)
+3.71%
0.335
Median (Q1–Q3)
83.50 (68.00–96.50)
85.50 (73.00–96.00)
+2.40%
0.076
sTF
Mean (SD)
130.06 (39.15)
177.50 (70.71)
+36.48%
<0.001
Median (Q1–Q3)
135.00 (97.50–159.50)
175.00 (124.00–215.00)
+29.63%
<0.001
APTT
Mean (SD)
29.13 (3.09)
25.69 (2.43)
−11.81%
<0.001
Median (Q1–Q3)
28.00 (27.00–30.50)
25.00 (24.00–27.00)
−10.71%
<0.001
∗For factor VII after 3 g n = 47, details in the text, ∗∗ percentage change of mean or median over baseline, ∗∗∗ value appropriately for paired t-test or Wilcoxon signed-rank test. APTT = activated partial thromboplastin time; AT = antithrombin; PC act. = protein C activity; PS act. = protein S activity; sTF = soluble tissue factor.
