Efficacy of Adjuvant Tamsulosin for Improving the Stone-Free Rate after Extracorporeal Shock Wave Lithotripsy in Renal Stones: A Randomized Controlled Trial

Table 3

Clinical features and the results of the randomized studies included for review.

Source	Treatment arms, subjects	Dosage	Study duration	Single ESWL	Single stone (in diameter)	Unicenter study	Results (SFR)	Intergroup comparison	Residual fragment (in diameter) evaluation
De Nunzio et al. [17], 2016	Tamsulosin, n = 19	0.4 mg/day	21 d	Yes	Renal (5–20 mm)	Yes	58%	= 0.399	(Not mentioned)
	Silodosin, n = 19	8 mg/day					47%		Ultrasound and
	Placebo, n = 22	--					55%		CT scan
Ahmed et al. [18], 2016	Tamsulosin, n = 123	0.4 mg/day	12 wk	Yes	Renal (≤20 mm)	No (four centers)	78%	= 0.108	(<4 mm)
	Standard, n = 126	--					69%		KUB plain X-ray,
									ultrasound, and CT scan
Zaytoun et al. [19], 2012	Tamsulosin, n = 50	0.4 mg/day	12 wk	No (1 to 4)	Renal (≤20 mm)	Yes	92%	> 0.050	(<3 mm)
	Doxazosin, n = 50	1–4 mg/day					90%		KUB plain X-ray and ultrasound
	Standard, n = 50	--					84%
Falahatkar et al. [20], 2011	Tamsulosin, n = 70	0.4 mg/day	30 d	Yes	Renal or ureteral (4–20 mm)	Yes	71%	> 0.050	(Not mentioned)
	Placebo, n = 71	Placebo					61%		KUB plain X-ray and ultrasound
Gravina et al. [11], 2005	Tamsulosin, n = 65	0.4 mg/day	12 wk	Yes	Renal (4–20 mm)	Yes	79%	= 0.037	(≤3 mm)
	Standard, n = 65	--					60%		KUB plain X-ray, ultrasound, and urography
Naja et al. [21], 2008	Tamsulosin, n = 51	0.4 mg/day	3 mo	No	Renal (5–20 mm)	Yes	94%	= 0.140	(≤3 mm)
	Standard, n = 65	--		(1 to 4)			85%		KUB plain X-ray and ultrasound
Hussein [13], 2010	Tamsulosin, n = 67	0.4 mg/day	4 wk	Yes	Renal (<25 mm) location limited	Yes	73%	= 0.008	(<3 mm)
	Standard, n = 69	--					55%		KUB plain X-ray and ultrasound
Bhagat et al. [15], 2007	Tamsulosin, n = 29	0.4 mg/day	30 d	Yes	Renal (6–24 mm)	Yes	97%	= 0.040	(<3 mm)
	Placebo, n = 29	--			Ureteral (6–15 mm)		79%		Not mentioned
Vicentini et al. [12], 2011	Tamsulosin, n = 38	0.4 mg/day	30 d	Yes	Renal	Yes	61%/62%	= 0.118	(≤4 mm)
	Nifedipine, n = 35	20 mg/day			(5–20 mm)/		49%/60%	= 0.024	KUB plain X-ray and ultrasound
	Placebo, n = 38	--			(10–20 mm)		37%/26%
Maldonado-Valadez et al., 2021	Tamsulosin, n = 28	0.4 mg/day	8 wk	Yes	Renal	Yes	54%/57%	= 0.680/	(≤4 mm)
	Standard, n = 29	--			(5–20 mm)/		48%/33%	= 0.198	KUB plain X-ray and CT scan
					(11–20 mm)

ESWL: extracorporeal shock wave lithotripsy; SFR: stone-free rate; KUB: kidneys, ureter, and bladder.