Association of BIRC5 Gene Polymorphism with the Collateral Circulation and Severity of Large Artery Atherosclerotic Stroke

Table 6

Association of BIRC5 SNP of rs2071214 with stroke severity.

Variables	NIHSS < 6n = 192	NIHSS ≥ 6 n = 236	^a	OR (95% CI)^a
rs 2071214
Additive model
AA	81 (42.19%)	74 (31.35%)	Ref	1.00
GA	85 (44.27%)	115 (48.73%)	0.042	1.717 (1.021–2.888)
GG	26 (13.54%)	47 (19.92%)	0.263	1.496 (0.739–3.027)
Dominant model
AA	81 (42.19%)	74 (31.36%)	Ref	1.00
GA/GG	111 (57.81%)	162 (68.64%)	0.043	1.658 (1.017–2.703)
Recessive model
AA/GA	166 (86.46%)	189 (80.08%)	Ref	1.00
GG	26 (13.54%)	47 (19.92%)	0.768	1.101 (0.580–2.092)

Logistic regression analysis was used to evaluate the distribution of genotype frequencies of rs2071214 polymorphisms in NIHSS < 6 and NIHSS ≥ 6 group. OR, odds ratio; CI, confidence interval; Ref, reference; NIHSS, National Institutes of Health Stroke Survey.^a Adjusted for age, smoking, HDL-C, collateral circulation, vascular stenosis degree.