|
(A) Within the test days |
| Control | 8 g salt | 12 g salt |
|
Diuresis (mL/min) |
2 hrs | 3.5 (1.4–4.3) | 1.1 (0.8–1.5) | 1.2 (0.8–1.8) |
4 hrs | 1.3 (0.8–2.0) | 1.2 (0.8–1.5) | 1.6 (1.0–1.9) |
P value | Baseline vs. 2 hrs: < 0.001a | Baseline vs. 2 hrs: 0.006a | Baseline vs. 2 hrs: 0.006a |
Baseline vs. 4 hrs: 0.026a | Baseline vs. 4 hrs: 0.021a | Baseline vs. 4 hrs: 0.001a |
Urine osmolality (mOsm/kg) |
2 hrs | 260 (166–910) | 927 (824–1072) | 905 (771–1056) |
4 hrs | 517 (384–742) | 900 (796–982) | 849 (764–960) |
P value | < 0.001∗∗ | NS | NS |
Free water clearance (mL/min) |
2 hrs | 0.3 (−2.6–1.4) | −2.2 (−3.0–(−1.5)) | −2.5 (−3.3–(−1.8)) |
4 hrs | −1.2 (−1.7–(−0.6)) | −2.7 (−2.9–(−1.5)) | −2.8 (−3.5–(−1.9)) |
P value | NS | Baseline vs. 2 hrs: 0.006a | Baseline vs. 2 hrs: <0.001a |
Baseline vs. 4 hrs: 0.021a | Baseline vs. 4 hrs: 0.002a |
Sodium/creatinine (mmol/mmol) |
2 hrs | 7.8 (6.3–12.7) | 12.4 (5.8–16.9) | 13.1 (11.6–20.5) |
4 hrs | 10.2 (6.5–16) | 23.6 (16.2–31.4) | 30.6 (26.3–38.6) |
P value | NS | < 0.001∗∗ | < 0.001∗∗ |
Potassium/creatinine (mmol/mmol) |
2 hrs | 5.7 (3.9–8.5) | 5.8 (4.1–7.8) | 6.2 (3.5–7.7) |
4 hrs | 9.4 (6.2–11) | 13 (9.7–15.1) | 12.5 (9.3–17.7) |
P value | Baseline vs. 2 hrs: 0.001a | Baseline vs. 4 hrs: <0.001a | Baseline vs. 4 hrs: <0.001a |
Baseline vs. 4 hrs: <0.001a | 2 hrs vs. 4 hrs: 0.003a | 2 hrs vs. 4 hrs: 0.004a |
Urea/creatinine (mmol/mmol) |
2 hrs | 30 (25–32) | 25 (21–32) | 28 (20–34) |
4 hrs | 28 (23–33) | 29 (22–36) | 28 (24–35) |
P value | Baseline vs. 2 hrs: 0.005a | Baseline vs. 4 hrs: 0.018a | Baseline vs. 4 hrs: 0.024a |
(B) Between the test days | | | |
| Control | 8 g salt | 12 g salt | P value |
|
Diuresis (mL/min) |
2 hrs | 3.5 (1.4–4.3) | 1.1 (0.8–1.5) | 1.2 (0.8–1.8) | 0.001∗ 0.002† |
4 hrs | 1.3 (0.8–2.0) | 1.2 (0.8–1.5) | 1.6 (1.0–1.9) | 0.010∆ |
Urine osmolality (mOsm/kg) |
2 hrs | 260 (166–910) | 927 (824–1072) | 905 (771–1056) | < 0.001∗ < 0.001† |
4 hrs | 517 (384–742) | 900 (796–982) | 849 (764–960) | 0.001∗ 0.003† 0.026∆ |
Free water clearance (mL/min) |
2 hrs | 0.3 (−2.6–1.4) | −2.2 (−3.0–(−1.5)) | −2.5 (−3.3–(−1.8)) | 0.002∗ 0.002† |
4 hrs | −1.2 (−1.7–(−0.6)) | −2.7 (−2.9–(−1.5)) | −2.8 (−3.5–(−1.9)) | 0.001∗ 0.013† |
Sodium/creatinine (mmol/mmol) |
2 hrs | 7.8 (6.3–12.7) | 12.4 (5.8–16.9) | 13.1 (11.6–20.5) | 0.006† 0.027∆ |
4 hrs | 10.2 (6.5–16) | 23.6 (16.2–31.4) | 30.6 (26.3–38.6) | 0.002∗ < 0.001† 0.006∆ |
Potassium/creatinine (mmol/mmol) |
2 hrs | 5.7 (3.9–8.5) | 5.8 (4.1–7.8) | 6.2 (3.5–7.7) | NS |
4 hrs | 9.4 (6.2–11) | 13 (9.7–15.1) | 12.5 (9.3–17.7) | < 0.001∗ 0.007† |
Urea/creatinine (mmol/mmol) |
2 hrs | 30 (25–32) | 25 (21–32) | 28 (20–34) | NS |
4 hrs | 28 (23–33) | 29 (22–36) | 28 (24–35) | NS |
|