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International Journal of Dentistry
Volume 2010, Article ID 107147, 5 pages
Clinical Study

Issues of Recruitment and Rationale for Conducting Clinical Trials on Mutans Streptococci Suppression in Mothers

1College of Dentistry, New York University, NY 10010, USA
2Faculdade de Odontologia de Bauru, Universidade de São Paulo, 17012-901 Bauru, Brazil
3Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
4School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA

Received 14 March 2010; Revised 5 July 2010; Accepted 8 July 2010

Academic Editor: Jukka H. Meurman

Copyright © 2010 Walter A. Bretz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aims of this study are (1) to describe issues related to recruitment of mothers participating in a clinical trial of transmission of mutans streptococci (MS) from mother to child in Bauru, Brazil and (2) to perform cross-cultural and temporal comparisons of levels of infection of the MS in mothers of Bauru. A total of 1422 mothers were visited at their domiciles. Cutoff levels for the MS were established at  CFU/mL saliva. The main reason for a mother not enrolling was not being highly infected by the MS, yet 76% of mothers presented with levels  CFU/mL saliva. Recent studies in industrialized countries showed a negative coefficient for linear tests indicating significant decline overtime in the levels of MS in mothers. Intercountry comparisons for mothers' salivary levels of the MS with the Bauru study as the reference revealed significant differences with studies conducted in the last two decades.