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International Journal of Dentistry
Volume 2010 (2010), Article ID 324719, 22 pages
http://dx.doi.org/10.1155/2010/324719
Review Article

Gene Polymorphisms in Chronic Periodontitis

1Department of Oral Microbiology, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije University, 1081 BT Amsterdam, The Netherlands
2Department of Periodontology, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije University, 1081 BT Amsterdam, The Netherlands

Received 29 June 2009; Revised 9 November 2009; Accepted 6 January 2010

Academic Editor: Barbara Noack

Copyright © 2010 Marja L. Laine et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We aimed to conduct a review of the literature for gene polymorphisms associated with chronic periodontitis (CP) susceptibility. A comprehensive search of the literature in English was performed using the keywords: periodontitis, periodontal disease, combined with the words genes, mutation, or polymorphism. Candidate gene polymorphism studies with a case-control design and reported genotype frequencies in CP patients were searched and reviewed. There is growing evidence that polymorphisms in the IL1, IL6, IL10, vitamin D receptor, and CD14 genes may be associated with CP in certain populations. However, carriage rates of the rare ( 𝑅 ) -allele of any polymorphism varied considerably among studies and most of the studies appeared under-powered and did not correct for other risk factors. Larger cohorts, well-defined phenotypes, control for other risk factors, and analysis of multiple genes and polymorphisms within the same pathway are needed to get a more comprehensive insight into the contribution of gene polymorphisms in CP.