Gene Polymorphisms in Chronic Periodontitis

Table 1

IL1A −889 (+4845) C>T gene polymorphisms and carriage rate of the Rare (R)-allele in case-control studies and association with susceptibility to chronic periodontitis.

	Patients		Controls
Ethnicity	n	R-allele	N	R-allele	Associated	Reference
of subjects		carriage		carriage	with periodontitis
Caucasian	322	43%	32	38%	−	Gore et al.1998 [5]
Caucasian	1052	64%	53	60%	−(+^4)	Laine et al. 2001 [6]
Caucasian	61	43%	800	50%	−	Thomson et al. 2001 [7]
Caucasian	841	48%	60	45%	−	Rogers et al. 2002 [8]
Caucasian	45	53%	110	43%	−	Sakellari et al. 2003 [9]
Caucasian	57	72%	100	56%	−	Brett et al. 2005 [10]
Caucasian	3303	44%	101	35%	−	Lopez et al. 2005 [11]
Caucasian	56	54%	90	49%	−	Sakellari et al. 2006 [12]
Caucasian	51	55%	178	43%	−	Tervonen et al. 2007 [13]
Caucasian	97	90%	97	79%	+	Wagner et al. 2007 [14]
Caucasian	8932	54%	493	49%	−	Struch et al. 2008 [15]
Caucasian	511	71%	168	60%	−	Geismar et al. 2008 [16]
Mixed1	83	69%	37	52%	−	Shirodaria et al. 2000 [17]
Asian (Thai)	54	8%	43	23%	−	Anusaksathien et al. 2003 [18]
Japanese	583	14%	44	16%	−	Kobayashi et al. 2007 [19]
Japanese	1003	20%	100	16%	−	Kobayashi et al. 2007 [20]
Brazilian	29	14%	17	23%	−	Gonçalves et al. 2006 [21]
Brazilian	67	60%	41	41%	+	Moreira et al. 2007 [22]

nr = not reported. − = association not found. += association found.
163% Caucasian; 22% Asian; 15% Afro-Caribean.
2Cases diagnosed as adult periodontitis.
3Cases diagnosed as mixed periodontitis status.
4An association with periodontitis was found for combined genotype: carriage of R-allele for IL1A −889, IL-1B +3954, and IL1RN in a subgroup of patients being nonsmokers, and at the same time culture negative for P. gingivalis and A. actinomycetemcomitans.