Gene Polymorphisms in Chronic Periodontitis

Table 10

The vitamin D receptor (VDR) gene polymorphisms and carriage rate of the Rare (R)-allele in case-control studies and association with susceptibility to chronic periodontitis.

		Patients		Controls
VDR gene	Ethnicity	n	R-allele	n	R-allele	Associated	Reference
polymorphism	of subjects		carriage		carriage	with periodontitis
Taq1 T>C	Caucasian	57	49%	100	78%	+	Brett et al. 2005 [10]
	Caucasian	58	53%	140	63%	+^3	Nibali et al. 2008 [81]
	Chinese1	24	4%	39	5%	−	Sun et al. 2002 [82]
	Japanese	74	11%	94	23%	+^4	Tachi et al. 2003 [83]
	Brazilian	69	67%	44	45%	+ (+^5)	de Brito et al. 2004 [84]
	Turkish	72	50%	102	42%	− (+^6)	Gunes et al. 2008 [85]
Bsm1 A>G	Japanese1	52	21%	55	20%	−	Yoshihara et al. 2001 [80]
	Japanese	17	23%	802	19%	− (+^7)	Naito et al. 2007 [86]
	Brazilian	69	86%	44	82%	− (+^5)	de Brito Junior et al. 2004 [84]
	Turkish	72	86%	102	91%	− (+^6)	Gunes et al. 2008 [85]
Fok1 A>G	Japanese	74	63%	94	54%	−	Tachi et al. 2003 [83]
	Japanese	17	47%	806	69%	−(+^7)	Naito et al. 2007 [86]
Apa1 G>T	Japanese	17	30%	806	53%	− (+^7)	Naito et al. 2007 [86]
	Turkish	72	54%	102	61%	− (+^6)	Gunes et al. 2008 [85]

nr = not reported. − = association not found. + = association found.
1Cases diagnosed as adult periodontitis.
2Control group consists of patients without severe periodontitis.
3The N/N genotype is associated with periodontitis in smokers.
4The N-allele is associated with periodontitis, also when adjusted for smoking and diabetes.
5The Bsm1/Taq1 N/N haplotype is associated with periodontitis.
6The Apa1/Bsm1/Taq1 haplotype is associated with severe periodontitis.
7The Apa1/Bsm1/Fok1 haplotype is associated with severe periodontitis.