International Journal of Dentistry / 2010 / Article / Tab 10

Review Article

Gene Polymorphisms in Chronic Periodontitis

Table 10

The vitamin D receptor (VDR) gene polymorphisms and carriage rate of the Rare (R)-allele in case-control studies and association with susceptibility to chronic periodontitis.

PatientsControls
VDR geneEthnicitynR-allelenR-alleleAssociatedReference
polymorphismof subjectscarriagecarriagewith periodontitis

Taq1 T>CCaucasian5749%10078% Brett et al. 2005 [10]
Caucasian5853%14063% Nibali et al. 2008 [81]
Chinese 244%395% Sun et al. 2002 [82]
Japanese7411%9423% Tachi et al. 2003 [83]
Brazilian6967%4445% ( )de Brito et al. 2004 [84]
Turkish7250%10242% ( )Gunes et al. 2008 [85]

Bsm1 A>GJapanese 5221%5520% Yoshihara et al. 2001 [80]
Japanese1723%80 19% ( )Naito et al. 2007 [86]
Brazilian6986%4482% ( )de Brito Junior et al. 2004 [84]
Turkish7286%10291% ( )Gunes et al. 2008 [85]

Fok1 A>GJapanese7463%9454% Tachi et al. 2003 [83]
Japanese1747%80 69% ( )Naito et al. 2007 [86]

Apa1 G>TJapanese1730%80 53% ( )Naito et al. 2007 [86]
Turkish7254%10261% ( )Gunes et al. 2008 [85]

nr = not reported. = association not found. = association found.
Cases diagnosed as adult periodontitis.
Control group consists of patients without severe periodontitis.
The N/N genotype is associated with periodontitis in smokers.
The N-allele is associated with periodontitis, also when adjusted for smoking and diabetes.
The Bsm1/Taq1 N/N haplotype is associated with periodontitis.
The Apa1/Bsm1/Taq1 haplotype is associated with severe periodontitis.
The Apa1/Bsm1/Fok1 haplotype is associated with severe periodontitis.