International Journal of Dentistry / 2010 / Article / Tab 2

Review Article

Gene Polymorphisms in Chronic Periodontitis

Table 2

IL1B +3954 (+3953) C>T gene polymorphisms and carriage rate of the Rare (R)-allele in case-control studies and association with susceptibility to chronic periodontitis.

PatientsControls
EthnicitynR-allelenR-alleleAssociatedReference
of subjectscarriagecarriagewith periodontitis

Caucasian32 43%3238% Gore et al. 1998 [5]
Caucasian40 50%4527% Galbraith et al. 1999 [25]
Caucasian105 49%5345% Laine et al. 2001 [6]
Caucasian6134%80041% Thomson et al. 2001 [7]
Caucasian84 35%6040% Rogers et al. 2002 [8]
Caucasian28 46%3348% Gonzales et al. 2003 [26]
Caucasian4549%11050% Sakellari et al. 2003 [9]
Caucasian5742%10041% Brett et al. 2005 [10]
Caucasian330 30%10113% Lopez et al. 2005 [11]
Caucasian3234%5240% Droździk et al. 2006 [27]
Caucasian1333%1333% Gustafsson et al. 2006 [28]
Caucasian5641%9044% Sakellari et al. 2006 [12]
Caucasian5149%17844% Tervonen et al. 2007 [13]
Caucasian9774%9743% Wagner et al. 2007 [14]
Caucasian51 57%16843% Geismar et al. 2008 [16]
Caucasian893 44%49339% Struch et al. 2008 [15]
Asian (Thai)540%432% Anusaksathien et al. 2003 [18]
Japanese64 6%6410% Soga et al. 2003 [29]
Japanese58 5%447% Kobayashi et al. 2007 [19]
Japanese100 6%1006% Kobayashi et al. 2007 [20]
Brazilian5244%3123% Moreira et al. 2005 [30]
Brazilian2928%1718% Gonçalves et al. 2006 [21]
Brazilian11739%17531% Ferreira et al. 2008 [31]
Indian3030%3123% Kaarthikeyan et al. 2009 [32]

nr = not reported. = association not found. = association found.
Cases diagnosed as adult periodontitis.
Cases diagnosed as mixed periodontitis status.
An association with periodontitis was found for combined genotype: carriage of R-allele for IL1A 889, IL1B +3954, and IL1RN in a subgroup of patients being nonsmokers, and at the same time culture negative for P. gingivalis and A. actinomycetemcomitans.
N-allele is associated with CP.
R-allele is not quit associated with CP