Gene Polymorphisms in Chronic Periodontitis

Table 5

TNFA gene polymorphisms and carriage rate of the Rare (R)-allele in case-control studies and association with susceptibility to chronic periodontitis.

		Patients		Controls
TNFA gene	Ethnicity	n	R-allele	n	R-allele	Associated	Reference
polymorphism	of subjects		carriage		carriage	with periodontitis
−1031 T>C	Japanese	642	36%	64	22%	+	Soga et al. 2003 [29]
−863 C>A	Japanese	642	39%	64	25%	+	Soga et al. 2003 [29]
−857 C>T	Japanese	642	39%	64	28%	+	Soga et al. 2003 [29]
−367 G>A	Mixed1	90	2%	264	2%	−	Craandijk et al. 2002 [42]
−308 G>A	Caucasian	322	28%	32	24%	−	Galbraith et al. 1998 [43]
	Caucasian	402	20%	45	24%	+^3	Galbraith et al. 1999 [25]
	Caucasian	132	21%	114	24%	−	Fassmann et al. 2003 [44]
	Caucasian	81	36%	80	28%	−	Folwaczny et al. 2004 [45]
	Caucasian	60	22%	39	18%	−	Donati et al. 2005 [46]
	Caucasian	57	35%	100	40%	−	Brett et al. 2005 [10]
	Caucasian	56	16%	90	27%	−	Sakellari et al. 2006 [12]
	Caucasian	51	31%	178	23%	−	Tervonen et al. 2007 [13]
	Caucasian	54	31%	52	35%	−	Schulz et al. 2008 [47]
	Mixed1	90	27%	264	29%	−	Craandijk et al. 2002 [42]
	Japanese	642	2%	64	3%	−	Soga et al. 2003 [29]
	Brazilian	74	31%	51	44%	−	De Menezes et al. 2008 [48]
−238 G>A	Caucasian	322	6%	32	6%	−	Galbraith et al. 1998 [43]
	Caucasian	54	9%	52	15%	−	Schulz et al. 2008 [47]
	Mixed1	90	6%	264	6%	−	Craandijk et al. 2002 [42]
	Japanese	642	0%	64	3%	−	Soga et al. 2003 [29]
+489 G>A	Mixed1	90	24%	264	19%	−	Craandijk et al. 2002 [42]

nr = not reported. − = association not found. + = association found.
181% of study population is of Caucasian heritage.
2Cases diagnosed as adult periodontitis.
3N/N genotype is associated with CP.