International Journal of Dentistry / 2010 / Article / Tab 5

Review Article

Gene Polymorphisms in Chronic Periodontitis

Table 5

TNFA gene polymorphisms and carriage rate of the Rare (R)-allele in case-control studies and association with susceptibility to chronic periodontitis.

PatientsControls
TNFA geneEthnicitynR-allelenR-alleleAssociatedReference
polymorphismof subjectscarriagecarriagewith periodontitis

1031 T>CJapanese64 36%6422% Soga et al. 2003 [29]

863 C>AJapanese64 39%6425% Soga et al. 2003 [29]

857 C>TJapanese64 39%6428% Soga et al. 2003 [29]

367 G>AMixed 902%2642% Craandijk et al. 2002 [42]

308 G>ACaucasian32 28%3224% Galbraith et al. 1998 [43]
Caucasian40 20%4524% Galbraith et al. 1999 [25]
Caucasian13221%11424% Fassmann et al. 2003 [44]
Caucasian8136%8028% Folwaczny et al. 2004 [45]
Caucasian6022%3918% Donati et al. 2005 [46]
Caucasian5735%10040% Brett et al. 2005 [10]
Caucasian5616%9027% Sakellari et al. 2006 [12]
Caucasian5131%17823% Tervonen et al. 2007 [13]
Caucasian5431%5235% Schulz et al. 2008 [47]
Mixed 9027%26429% Craandijk et al. 2002 [42]
Japanese64 2%643% Soga et al. 2003 [29]
Brazilian7431%5144% De Menezes et al. 2008 [48]

238 G>ACaucasian32 6%326% Galbraith et al. 1998 [43]
Caucasian549%5215% Schulz et al. 2008 [47]
Mixed 906%2646% Craandijk et al. 2002 [42]
Japanese64 0%643% Soga et al. 2003 [29]

489 G>AMixed 9024%26419% Craandijk et al. 2002 [42]

nr = not reported. = association not found. = association found.
81% of study population is of Caucasian heritage.
Cases diagnosed as adult periodontitis.
N/N genotype is associated with CP.