Gene Polymorphisms in Chronic Periodontitis

Table 6

IL4 and IL4RA gene polymorphisms and carriage of the Rare (R)-allele in case-control studies, and association with chronic susceptibility to periodontitis.

		Patients		Controls
IL4 gene	Ethnicity of subjects	n	R-allele	n	R-allele	Associated	Reference
polymorphism			carriage		carriage	with periodontitis
−33 C>T	Caucasian	194	32%	158	25%	− (+^2)	Holla et al. 2008 [49]
	Brazilian	69	68%	44	57%	−	Scarel-Caminaga et al. 2003 [50]
	African-American	301	87%	30	81%	−	Pontes et al. 2004 [51]
−590 C>T	Caucasian	194	32%	158	25%	− (+^2)	Holla et al. 2008 [49]
	Iranian	26	33%	56	52%	−	Hooshmand et al. 2008 [52]
	African-American	301	67%	30	57%	−	Pontes et al. 2004 [51]
VNTR intron 3	Caucasian	194	31%	158	25%	− (+^2)	Holla et al. 2008 [49]
RA Q551R	Caucasian	60	45%	39	39%	−	Donati et al. 2005 [46]

nr = not reported. − = association not found. + = association found.
1Cases diagnosed as mixed periodontitis status.
2Haplotype T(−590)/T(−33)/allele 2 (70 bp) is associated with CP (17.0% cp versus 11.0%; OR 1.85).