International Journal of Dentistry / 2010 / Article / Tab 6

Review Article

Gene Polymorphisms in Chronic Periodontitis

Table 6

IL4 and IL4RA gene polymorphisms and carriage of the Rare (R)-allele in case-control studies, and association with chronic susceptibility to periodontitis.

PatientsControls
IL4 geneEthnicity of subjectsnR-allelenR-alleleAssociatedReference
polymorphismcarriagecarriagewith periodontitis

33 C>TCaucasian19432%15825% ( )Holla et al. 2008 [49]
Brazilian6968%4457% Scarel-Caminaga et al. 2003 [50]
African-American30 87%3081% Pontes et al. 2004 [51]

590 C>TCaucasian19432%15825% ( )Holla et al. 2008 [49]
Iranian2633%5652% Hooshmand et al. 2008 [52]
African-American30 67%3057% Pontes et al. 2004 [51]

VNTR intron 3Caucasian19431%15825% ( )Holla et al. 2008 [49]

RA Q551RCaucasian6045%3939% Donati et al. 2005 [46]

nr = not reported. = association not found. = association found.
Cases diagnosed as mixed periodontitis status.
Haplotype T( 590)/T( 33)/allele 2 (70 bp) is associated with CP (17.0% cp versus 11.0%; OR 1.85).