International Journal of Dentistry

Review Article

Gene Polymorphisms in Chronic Periodontitis

Table 9

FcγRIIa, FcγRIIIa, and FcγRIIIb gene polymorphisms and carriage rate of the Rare (R)-allele in case-control studies and association with susceptibility to chronic periodontitis.


		Patients		Controls
gene	Ethnicity	n	R-allele	N	R-allele	Associated	Reference
polymorphism	of subjects	n	carriage	N	carriage	with periodontitis	Reference

IIa 131 H>R	Caucasian	54	76%	24	71%		Colombo et al. 1998 [70]
	Caucasian	56	70%	61	75%		Loos et al. 2003 [71]
	Caucasian	213	63%	209	75%	()	Yamamoto et al. 2004 [72]
	Caucasian	132	72%	72	74%		Wolf et al. 2006 [73]
	Japanese	100	44%	105	40%		Kobayashi et al. 1997 [74]
	Japanese	83	46%	104	39%		Kobayashi et al. 2000 [75]
	Japanese	89	42%	64	42%		Kobayashi et al. 2001 [76]
	Taiwanese	50	50%	74	62%		Chung et al. 2003 [77]
	Japanese	58	48%	44	36%		Kobayashi et al. 2007 [19]
	Japanese	100	44%	100	39%		Kobayashi et al. 2007 [20]

IIIa 158 F>V	Caucasian	56	73%	61	59%		Loos et al. 2003 [71]
	Japanese	100	42%	104	46%		Sugita et al. 1999 [78]
	Japanese	83	43%	104	46%		Kobayashi et al. 2000 [75]
	Japanese	89	49%	64	39%		Kobayashi et al. 2001 [76]
	Japanese	58	40%	44	45%		Kobayashi et al. 2007 [19]
	Japanese	100	45%	100	45%		Kobayashi et al. 2007 [20]

IIIb NA1> NA2	Caucasian	54	89%	24	75%		Colombo et al. 1998 [70]
	Caucasian	56	88%	61	92%		Loos et al. 2003 [71]
	Caucasian	132	84%	72	89%		Wolf et al. 2006 [73]
	Japanese	100	63%	105	64%		Kobayashi et al. 1997 [74]
	Japanese	83	64%	104	64%		Kobayashi et al. 2000 [75]
	Japanese	89	62%	64	56%		Kobayashi et al. 2001 [76]
	Japanese	73	74%	46	56%		Sugita et al. 2001 [79]
	Japanese	52	58%	55	57%		Yoshihara et al. 2001 [80]
	Taiwanese	50	62%	74	55%		Chung et al. 2003 [77]
	Japanese	58	66%	44	55%		Kobayashi et al. 2007 [19]
	Japanese	100	66%	100	64%		Kobayashi et al. 2007 [20]

nr = not reported. = association not found. = association found.
Mainly Caucasian, actual % of subjects of non-Caucasian heritage is not provided.
Cases diagnosed as adult periodontitis.
Cases diagnosed as mixed periodontitis status
N-allele is associated with periodontitis in smokers.