The Current and Future Therapies of Bone Regeneration to Repair Bone Defects
A schematic model for the differentiation of mesenchymal stem cells into tissue-specific cells by specific transcriptional factors. Mesenchymal stem cells can differentiate into osteoblasts, chondrocytes, myoblasts, and adipocytes. Each differentiation program is regulated by specific transcription factors: Runx2/Osterix, Sox5/6/9, MyoD family, and PPARγ, respectively.
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