Current Status and Future Development of Cell Transplantation Therapy for Periodontal Tissue Regeneration

Figure 1

Periodontal tissue regeneration using PDL cell sheets. (a) Sheets of polyglycolic acid (arrowhead) with or without the cell sheets were applied onto the root surfaces of canine mandibular premolars. (b) Bone defects were filled with 𝛽-TCP. (c, e) Thick, newly formed cementum (arrow) and dense collagen fibres were observed in the PDL of the PDL sheet-transplanted group. (d, f) The immunohistochemical detection of neurofilament protein revealed that newly formed nerve fibres were only observed in the group given the PDL sheets (arrow). Scale bars: 100 μm in (c) and (e); 50 μm in (d) and (f). B: newly formed bone, P: periodontal ligament, and D: root dentin. Modified from [13] with permission.