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International Journal of Dentistry
Volume 2012, Article ID 405292, 7 pages
Review Article

The Effect of Alternating Current Iontophoresis on Rats with the Chronic Constriction Injury to the Infraorbital Nerve

1Department of Orofacial Pain Management, Tokyo Medical and Dental University, Yushima, Bunkyo-ku, Tokyo 113-8549, Japan
2TTI ellebeau, Inc., Shinkan Building, Higashi-shinagawa, Shinagawa-ku, Tokyo 140-0002, Japan
3Department of Anesthesiology and Clinical Physiology, Tokyo Medical and Dental University, Yushima, Bunkyo-ku, Tokyo 113-8549, Japan

Received 16 December 2011; Revised 7 March 2012; Accepted 20 March 2012

Academic Editor: Yuzuru Kaneko

Copyright © 2012 Yoko Yamazaki et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This study aimed to examine the effect of AC iontophoresis on rats with the chronic constriction injury (CCI) to the infraorbital nerve by animal experiments. CCI model rats were divided into four groups, namely, rats that received general anesthesia for 60 min except AC IOP (CCI: ), AC IOP with 0.9% physiological saline for 60 min (CCI + saline AC IOP: ), AC IOP with 4% lidocaine hydrochloride for 60 min (CCI + lidocaine AC IOP: ), and attachment of two electrodes soaked with 4% lidocaine hydrochloride to the facial skin for 60 min (CCI + attach lidocaine: ). In the CCI + lidocaine AC IOP group, an elevated withdrawal threshold was observed after AC IOP, and the duration of efficacy was longer compared with that in the CCI + saline AC IOP and CCI + attached lidocaine groups. A significant decrease in the number of Fos-like immunoreactive (LI) cells was observed in the CCI + lidocaine AC IOP group compared with that in the CCI group. These findings suggest that the effect of CCI + lidocaine AC IOP group may be caused by active permeation of lidocaine into the facial skin and electrical stimulation of the trigeminal nucleus.