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International Journal of Dentistry
Volume 2012, Article ID 409496, 8 pages
Research Article

Application of Laser-Induced Bone Therapy by Carbon Dioxide Laser Irradiation in Implant Therapy

Division of Operative Dentistry, Department of Conservative Dentistry, Ohu University School of Dentistry, Ohu University School of Dentistry, 31-1 Misumido, Tomita machi, Koriyama, Fukushima 963-8611, Japan

Received 1 September 2011; Accepted 1 November 2011

Academic Editor: Chiaki Kitamura

Copyright © 2012 Takahiro Naka and Satoshi Yokose. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This study evaluated the application of laser-induced bone therapy (LIBT) to reduce implant healing time in rat tibia. Twenty 10-week-old female Sprague-Dawlay rats were used. The rats received laser irradiation (laser group) or sham operation (control group) on either side of the tibia. Five days after invasion, titanium implants were inserted in proximal tibia. Five, 10, and 20 days after implant placement, tibiae were collected. After taking micro-CT and performing a torque test, the tibiae were decalcified and 8-μm-thick sections were prepared. Specimens were stained with hematoxylin and eosin. Results. Micro-CT images, removal torque values, and histomorphometric analysis data demonstrated a significantly accelerated bone formation in the laser group earlier in the healing process. Conclusion. The use of laser irradiation was effective in promoting bone formation and acquiring osseointegration of titanium implants inserted in rat tibia. LIBT may be suitable for use in implant therapy.