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International Journal of Dentistry
Volume 2012, Article ID 628406, 5 pages
Review Article

Melatonin: Bone Metabolism in Oral Cavity

Department of Advance General Dental Master, School of Dentistry, Universidad Autónoma de Nuevo León, Hidalgo 2425-403, Col. Obispado, Monterrey, NL, Mexico

Received 25 January 2012; Accepted 11 June 2012

Academic Editor: Francesco Carinci

Copyright © 2012 Fanny López-Martínez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Throughout life, bone tissue undergoes a continuous process of resorption and formation. Melatonin, with its antioxidant properties and its ability to detoxify free radicals, as suggested by Conconi et al. (2000) may interfere in the osteoclast function and thereby inhibit bone resorption, as suggested by Schroeder et al. (1981). Inhibition of bone resorption may be enhanced by a reaction of indoleamine in osteoclastogenesis. That it has been observed melatonin, at pharmacological doses, decrease bone mass resorption by suppressing through down regulation of the RANK-L, as suggested by Penarrocha Diago et al. (2005) and Steflik et al. (1994). These data point an osteogenic effect towards that may be of melatonin of clinical importance, as it could be used as a therapeutic agent in situations in which would be advantageous bone formation, such as in the treatment of fractures or osteoporosis or their use as, a bioactive surface on implant as suggested by Lissoni et al. (1991).