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International Journal of Dentistry
Volume 2012, Article ID 856470, 5 pages
http://dx.doi.org/10.1155/2012/856470
Review Article

Innovative Approaches to Regenerate Enamel and Dentin

1Department of Orthodontics and Pediatric Dentistry, School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA
2Department of Otolaryngology, Head and Neck Surgery and Oncology, School of Medicine, University of Michigan, Ann Arbor, MI 48109, USA
3Department of Biological and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA
4Center for Organogenesis and Center for Computational Medicine and Bioinformatics, School of Medicine, University of Michigan, Ann Arbor, MI 48109, USA

Received 18 January 2012; Accepted 20 February 2012

Academic Editor: Gianpaolo Papaccio

Copyright © 2012 Xanthippi Chatzistavrou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The process of tooth mineralization and the role of molecular control of cellular behavior during embryonic tooth development have attracted much attention the last few years. The knowledge gained from the research in these fields has improved the general understanding about the formation of dental tissues and the entire tooth and set the basis for teeth regeneration. Tissue engineering using scaffold and cell aggregate methods has been considered to produce bioengineered dental tissues, while dental stem/progenitor cells, which can differentiate into dental cell lineages, have been also introduced into the field of tooth mineralization and regeneration. Some of the main strategies for making enamel, dentin, and complex tooth-like structures are presented in this paper. However, there are still significant barriers that obstruct such strategies to move into the regular clinic practice, and these should be overcome in order to have the regenerative dentistry as the important mean that can treat the consequences of tooth-related diseases.