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International Journal of Dentistry
Volume 2012, Article ID 896143, 8 pages
http://dx.doi.org/10.1155/2012/896143
Clinical Study

A Comparative Evaluation of the Efficacy of Two Novel Desensitising Dentifrices

1GlaxoSmithKline Consumer Healthcare, Surrey Weybridge, KT13 0DE, UK
2Sino-American Tianjin SmithKline and French Laboratories Ltd., Beijing, China
3Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, LuoYu Road 237, Wuhan 430070, China
4Genesis Oral Bioscience, Consultancy & Scientific Writing, Regents Mews, Surrey, Horley RH6 7AN, UK

Received 27 August 2012; Revised 21 October 2012; Accepted 21 October 2012

Academic Editor: Michelle A. Chinelatti

Copyright © 2012 Ashley P. Barlow et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. N. X. West, “Dentine hypersensitivity: preventive and therapeutic approaches to treatment,” Periodontology 2000, vol. 48, no. 1, pp. 31–41, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. C. R. Irwin and P. McCusker, “Prevalence of dentine hypersensitivity in a general dental population,” Journal of the Irish Dental Association, vol. 43, no. 1, pp. 7–9, 1997. View at Google Scholar · View at Scopus
  3. Q. Kehua, F. Yingying, S. Hong, W. Menghong, H. Deyu, and F. X. Chengdu, “A cross-sectional study of dentine hypersensitivity in China,” International Dental Journal, vol. 59, no. 6, pp. 376–380, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. Canadian Advisory Board on Dentin Hypersensitivity, “Consensus-based recommendations for the diagnosis and management of dentin hypersensitivity,” Journal of the Canadian Dental Association, vol. 69, pp. 221–226, 2003. View at Google Scholar
  5. G. R. Holland, M. N. Narhi, M. Addy, L. Gangarosa, and R. Orchardson, “Guidelines for the design and conduct of clinical trials on dentine hypersensitivity,” Journal of Clinical Periodontology, vol. 24, no. 11, pp. 808–813, 1997. View at Google Scholar · View at Scopus
  6. B. Gibson, O. V. Boiko, S. Baker et al., “The everyday impact of dentine sensitivity: personal and functional aspects,” Social Science and Dentistry, vol. 1, pp. 11–20, 2010. View at Google Scholar
  7. O. V. Boiko, S. R. Baker, B. J. Gibson et al., “Construction and validation of the quality of life measure for dentine hypersensitivity (DHEQ),” Journal of Clinical Periodontology, vol. 37, no. 11, pp. 973–980, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. C. R. Parkinson and A. Sasov, “High-resolution non-destructive 3D interrogation of dentin using X-ray nanotomography,” Dental Materials, vol. 24, no. 6, pp. 773–777, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Kawabata, M. P. Hector, G. R. Davis, C. R. Parkinson, G. D. Rees, and P. Anderson, “Diffusive transport within dentinal tubules: an X-ray microtomographic study,” Archives of Oral Biology, vol. 53, no. 8, pp. 736–743, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. E. G. Absi, M. Addy, and D. Adams, “Dentine hypersensitivity. A study of the patency of dentinal tubules in sensitive and non-sensitive cervical dentine,” Journal of Clinical Periodontology, vol. 14, no. 5, pp. 280–284, 1987. View at Google Scholar · View at Scopus
  11. M. Brännström and A. Åström, “A study on the mechanism of pain elicited from the dentin,” Journal of Dental Research, vol. 43, pp. 619–625, 1964. View at Google Scholar · View at Scopus
  12. M. Brännström, L. A. Lindén, and A. Aström, “The hydrodynamics of the dental tubule and of pulp fluid. A discussion of its significance in relation to dentinal sensitivity,” Caries Research, vol. 1, no. 4, pp. 310–317, 1967. View at Google Scholar · View at Scopus
  13. M. Brännström and G. Johnson, “Movements of the dentine and pulp liquids on application of thermal stimuli: an in vitro study,” Acta Odontologica Scandinavica, vol. 28, no. 1, pp. 59–70, 1970. View at Google Scholar · View at Scopus
  14. R. Orchardson and W. J. Collins, “Clinical features of hypersensitive teeth,” British Dental Journal, vol. 162, no. 7, pp. 253–256, 1987. View at Google Scholar · View at Scopus
  15. C. T. Bamise, A. O. Olusile, and A. O. Oginni, “An analysis of the etiological and predisposing factors related to dentin hypersensitivity,” Journal of Contemporary Dental Practice, vol. 9, no. 5, pp. 52–59, 2008. View at Google Scholar · View at Scopus
  16. M. Hodosh, “A superior desensitizer—potassium nitrate,” The Journal of the American Dental Association, vol. 88, no. 4, pp. 831–832, 1974. View at Google Scholar · View at Scopus
  17. A. R. Salvato, G. E. Clark, J. Gingold, and F. A. Curro, “Clinical effectiveness of a dentifrice containing potassium chloride as a desensitizing agent,” American Journal of Dentistry, vol. 5, no. 6, pp. 303–306, 1992. View at Google Scholar · View at Scopus
  18. G. Silverman, J. Gingold, and F. A. Curro, “Desensitizing effect of a potassium chloride dentifrice,” American Journal of Dentistry, vol. 7, no. 1, pp. 9–12, 1994. View at Google Scholar · View at Scopus
  19. R. Orchardson and D. G. Gillam, “The efficacy of potassium salts as agents for treating dentin hypersensitivity,” Journal of Orofacial Pain, vol. 14, no. 1, pp. 9–19, 2000. View at Google Scholar · View at Scopus
  20. O. Ajcharanukul, P. Kraivaphan, S. Wanachantararak, N. Vongsavan, and B. Matthews, “Effects of potassium ions on dentine sensitivity in man,” Archives of Oral Biology, vol. 52, no. 7, pp. 632–639, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. W. Chidchuangchai, N. Vongsavan, and B. Matthews, “Sensory transduction mechanisms responsible for pain caused by cold stimulation of dentine in man,” Archives of Oral Biology, vol. 52, no. 2, pp. 154–160, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. K. Markowitz and D. H. Pashley, “Discovering new treatments for sensitive teeth: the long path from biology to therapy,” Journal of Oral Rehabilitation, vol. 35, no. 4, pp. 300–315, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. D. H. Pashley, “Dentin permeability, dentin sensitivity, and treatment through tubule occlusion,” Journal of Endodontics, vol. 12, no. 10, pp. 465–474, 1986. View at Google Scholar · View at Scopus
  24. K. B. Muzzin and R. Johnson, “Effects of potassium oxalate on dentin hypersensitivity in vivo,” Journal of Periodontology, vol. 60, no. 3, pp. 151–158, 1989. View at Google Scholar · View at Scopus
  25. J. Camps and D. Pashley, “In vivo sensitivity of human root dentin to air blast and scratching,” Journal of Periodontology, vol. 74, no. 11, pp. 1589–1594, 2003. View at Publisher · View at Google Scholar · View at Scopus
  26. I. Gedalia, L. Brayer, N. Kalter, M. Richter, and A. Stabholz, “The effect of fluoride and strontium application on dentin: in vivo and in vitro studies,” Journal of Periodontology, vol. 49, no. 5, pp. 269–272, 1978. View at Google Scholar · View at Scopus
  27. S. Minkoff and S. Axelrod, “Efficacy of strontium chloride in dental hypersensitivity,” Journal of Periodontology, vol. 58, no. 7, pp. 470–474, 1987. View at Google Scholar · View at Scopus
  28. B. Topbaşi, C. Türkmen, and M. Günday, “An investigation of the effect of a desensitizing dentifrice on dentinal tubules in vitro and in vivo,” Quintessence International, vol. 29, no. 3, pp. 197–199, 1998. View at Google Scholar · View at Scopus
  29. S. Mason, N. Hughes, F. Sufi et al., “A comparative clinical study investigating the efficacy of a dentifrice containing 8% strontium acetate and 1040 ppm fluoride in a silica base and a control dentifrice containing 1450 ppm fluoride in a silica base to provide immediate relief of dentin hypersensitivity,” Journal of Clinical Dentistry, vol. 21, no. 2, pp. 42–48, 2010. View at Google Scholar · View at Scopus
  30. J. Camps, S. Pizant, J. Dejou, and J. C. Franquin, “Effects of desensitizing agents on human dentin permeability,” American Journal of Dentistry, vol. 11, no. 6, pp. 286–290, 1998. View at Google Scholar · View at Scopus
  31. J. C. Pereira, A. D. Segala, and D. G. Gillam, “Effect of desensitizing agents on the hydraulic conductance of human dentin subjected to different surface pre-treatments-an in vitro study,” Dental Materials, vol. 21, no. 2, pp. 129–138, 2005. View at Publisher · View at Google Scholar · View at Scopus
  32. A. F. Leme, J. C. dos Santos, M. Giannini, and R. S. Wada, “Occlusion of dentin tubules by desensitizing agents,” American Journal of Dentistry, vol. 17, no. 5, pp. 368–372, 2004. View at Google Scholar · View at Scopus
  33. J. L. Kolker, M. A. Vargas, S. R. Armstrong, and D. V. Dawson, “Effect of desensitizing agents on dentin permeability and dentin tubule occlusion,” Journal of Adhesive Dentistry, vol. 4, no. 3, pp. 211–221, 2002. View at Google Scholar · View at Scopus
  34. X. Yu, B. Liang, X. Jin, B. Fu, and M. Hannig, “Comparative in vivo study on the desensitizing efficacy of dentin desensitizers and one-bottle self-etching adhesives,” Operative Dentistry, vol. 35, no. 3, pp. 279–286, 2010. View at Publisher · View at Google Scholar · View at Scopus
  35. D. Cummins, “Dentin hypersensitivity: from diagnosis to a breakthrough therapy for everyday sensitivity relief,” Journal of Clinical Dentistry, vol. 20, no. 1, pp. 1–9, 2009. View at Google Scholar · View at Scopus
  36. I. Kleinberg, “SensiStat. A new saliva-based composition for simple and effective treatment of dentinal sensitivity pain,” Dentistry Today, vol. 21, no. 12, pp. 42–47, 2002. View at Google Scholar · View at Scopus
  37. I. Kleinberg, “A new saliva-based anticaries composition,” Dentistry Today, vol. 18, no. 2, pp. 98–103, 1999. View at Google Scholar · View at Scopus
  38. I. Petrou, R. Heu, M. Stranick et al., “A breakthrough therapy for dentin hypersensitivity: how dental products containing 8% arginine and calcium carbonate work to deliver effective relief of sensitive teeth,” Journal of Clinical Dentistry, vol. 20, no. 1, pp. 23–31, 2009. View at Google Scholar · View at Scopus
  39. F. Ayad, N. Ayad, Y. P. Zhang, W. DeVizio, D. Cummins, and L. R. Mateo, “Comparing the efficacy in reducing dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a commercial sensitive toothpaste containing 2% potassium ion: an eight-week clinical study on Canadian adults,” Journal of Clinical Dentistry, vol. 20, no. 1, pp. 10–16, 2009. View at Google Scholar · View at Scopus
  40. R. Docimo, L. Montesani, P. Maturo et al., “Comparing the efficacy in reducing dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a commercial sensitive toothpaste containing 2% potassium ion: an eight-week clinical study in Rome, Italy,” Journal of Clinical Dentistry, vol. 20, no. 1, pp. 137–143, 2009. View at Google Scholar · View at Scopus
  41. S. Mason, N. Hughes, and T. Layer, “Considerations for the development of over-the-counter dentifrices for the treatment and relief of dentin sensitivity,” Journal of Clinical Dentistry, vol. 20, no. 5, pp. 167–173, 2009. View at Google Scholar · View at Scopus
  42. D. Santos, L. Schaeffer, L. Du-Thumm, M. Vandeven, and D. Cummins, “Comparing the effects of brushing with a new gel-to-foam dentifrice to brushing with regular fluoride control dentifrices on viable bacteria levels in saliva,” American Journal of Dentistry, vol. 22, no. 5, pp. 315–320, 2009. View at Google Scholar · View at Scopus
  43. R. S. Leight, F. Sufi, R. Gross, S. C. Mason, and A. P. Barlow, “Dentinal hypersensitivity: a 12-week study of a novel dentifrice delivery system comparing different brushing times and assessing the efficacy for hard-to-reach molar teeth,” Journal of Clinical Dentistry, vol. 19, no. 4, pp. 147–153, 2008. View at Google Scholar · View at Scopus
  44. ICH Topic 6 Guideline for Good Clinical Practice CPMP/ICH/135/95, 1996.
  45. L. Laster, K. W. Laudenbach, and N. H. Stoller, “An evaluation of clinical tooth mobility measurements,” Journal of Periodontology, vol. 46, no. 10, pp. 603–607, 1975. View at Google Scholar · View at Scopus
  46. R. Leight, J. Bowman, and A. Barlow, “Pain measurement: long-term stability of VAS pain intensity ratings assessed by means of a pain scale calibration exercise,” Journal of Pain, vol. 9, no. S4, article 73, 2008. View at Google Scholar
  47. T. Schiff, L. Saletta, R. A. Baker, J. L. Winston, and T. He, “Desensitizing effect of a stabilized stannous fluoride/Sodium hexametaphosphate dentifrice,” Compendium of Continuing Education in Dentistry, vol. 26, no. 9, pp. 35–40, 2005. View at Google Scholar · View at Scopus
  48. K. Bekes, M. T. John, H. G. Schaller, and C. Hirsch, “Oral health-related quality of life in patients seeking care for dentin hypersensitivity,” Journal of Oral Rehabilitation, vol. 36, no. 1, pp. 45–51, 2009. View at Publisher · View at Google Scholar · View at Scopus