Three-Dimensional Reconstruction of Oral Tongue Squamous Cell Carcinoma at Invasion Front
Table 2
Results of 3D morphometry of 14 OTSCC cases.
OTSCC cases
Invasion mode(1)
Tissue volume(2)
Border area () mm2
/ mm−1
Ki67(+) nucleiin cancer cells(4)
Discohesivecancer foci(5)
Total
Parenchyma () (%)
Number
×104/mm3
Number
% volume
A
DS
2.88
0.19 (6.6)
17.2
90.5
20,805
[10.9]
65
(2.83)
B
PB
2.86
0.96 (33.6)
48.3
50.3
221,803
[23.1]
2
(0.0010)
C
PB
2.95
0.56 (21.4)
61.4
97.5
61,896
[9.8]
30
(0.060)
D
PB
2.91
0.37 (12.7)
30.9
83.5
47,913
[12.9]
53
(0.0089)
E
TSC
2.74
0.47 (17.2)
18.3
38.9
23,702
[5.0]
19
(0.44)
F
PB
2.58
0.43 (16.7)
31.3
72.8
108,234
[25.1]
116
(0.26)
G
TSC
2.94
0.20 (6.8)
27.2
136.0
29,009
[14.5]
76
(0.59)
H
PB
2.19
0.92 (42.0)
81.8
88.9
88,303
[9.6]
19
(0.024)
I
TSC
2.91
0.49 (16.8)
24.4
49.8
80,410
[16.4]
7
(0.088)
J
TSC
2.59
0.11 (4.2)
11.2
101.8
18,435
[16.8]
36
(0.33)
K
SF
2.39
0.031 (1.3)
3.8
122.6
4,193
[13.5]
117
(27.1)
L
DS
2.73
0.11 (4.0)
18.4
167.3
35,156
[32.0]
232
(3.76)
M
DS
2.74
0.19 (6.9)
28.8
151.6
45,217
[23.8]
159
(8.34)
N
SF
2.91
0.032 (1.1)
27.2
850.0
9,751
[30.5]
35
(1.69)
The abbreviations used are PB, pushing and bulky architecture; TSC, trabecular architecture with strands and cords; DS, diffuse spreading; and SF, special forms.
(2)The volume data correspond to the reconstructed total tissue volume and the segmented tumor parenchymal volume (). The number in parentheses indicates the volume ratio of to the total tissue.
(3)/ indicates the ratio between tumor parenchyma-stroma border area () and tumor parenchyma volume ().
(4)The number in brackets indicates the number of Ki67-positive nuclei per tumor parenchyma volume ().
(5)The number in parentheses indicates the volume ratio of discohesive cancer foci to tumor parenchymal volume ().
