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International Journal of Dentistry
Volume 2014 (2014), Article ID 107690, 8 pages
http://dx.doi.org/10.1155/2014/107690
Clinical Study

Conservative Surgical Management of Stage I Bisphosphonate-Related Osteonecrosis of the Jaw

1Unit of Oral Pathology and Laser-Assisted Oral Surgery, Department of Biomedical, Biotechnological and Translational Sciences, University of Parma, 43100 Parma, Italy
2Université de Liège, 4000 Liège, Belgium
3University of Valencia, 46010 Valencia, Spain

Received 31 October 2013; Accepted 21 December 2013; Published 6 February 2014

Academic Editor: Toni Zeinoun

Copyright © 2014 Paolo Vescovi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Landesberg, V. Woo, S. Cremers et al., “Potential pathophysiological mechanisms in osteonecrosis of the jaw,” Annals of the New York Academy of Sciences, vol. 1218, no. 1, pp. 62–79, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. J. Bagan, C. Scully, V. Sabater, and Y. Jimenez, “Osteonecrosis of the jaws in patients treated with intravenous bisphosphonates (BRONJ): a concise update,” Oral Oncology, vol. 45, no. 7, pp. 551–554, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. S. L. Ruggiero, T. B. Dodson, L. A. Assael, R. Landesberg, R. E. Marx, and B. Mehrotra, “American association of oral and maxillofacial surgeons position paper on bisphosphonate-related osteonecrosis of the jaws—2009 update,” Journal of Oral and Maxillofacial Surgery, vol. 67, no. 5, supplement, pp. 2–12, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. P. Vescovi, E. Merigo, M. Meleti, and M. Manfredi, “Early surgical approach preferable to medical therapy for bisphosphonate-related osteonecrosis of the jaws,” Journal of Oral and Maxillofacial Surgery, vol. 66, no. 4, pp. 831–832, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. J. D. Bashutski, R. M. Eber, J. S. Kinney et al., “Teriparatide and osseous regeneration in the oral cavity,” The New England Journal of Medicine, vol. 363, no. 25, pp. 2396–2405, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Cheung and E. Seeman, “Teriparatide therapy for alendronate-associated osteonecrosis of the jaw,” The New England Journal of Medicine, vol. 363, no. 25, pp. 2473–2474, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. M. S. Epstein, F. W. Wicknick, J. B. Epstein, J. R. Berenson, and M. Gorsky, “Management of bisphosphonate-associated osteonecrosis: pentoxifylline and tocopherol in addition to antimicrobial therapy. An initial case series,” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, vol. 110, no. 5, pp. 593–596, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. T. Ziebart, F. Koch, M. O. Klein et al., “Geranylgeraniol—a new potential therapeutic approach to bisphosphonate associated osteonecrosis of the jaw,” Oral Oncology, vol. 47, no. 3, pp. 195–201, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Agrillo, M. T. Petrucci, M. Tedaldi et al., “New therapeutic protocol in the treatment of avascular necrosis of the jaws,” Journal of Craniofacial Surgery, vol. 17, no. 6, pp. 1080–1083, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. C. I. Ripamonti, E. Cislaghi, L. Mariani, and M. Maniezzo, “Efficacy and safety of medical ozone (O3) delivered in oil suspension applications for the treatment of osteonecrosis of the jaw in patients with bone metastases treated with bisphosphonates: preliminary results of a phase I-II study,” Oral Oncology, vol. 47, no. 3, pp. 185–190, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. J. J. Freiberger, R. Padilla-Burgos, A. H. Chhoeu et al., “Hyperbaric oxygen treatment and bisphosphonate-induced osteonecrosis of the jaw: a case series,” Journal of Oral and Maxillofacial Surgery, vol. 65, no. 7, pp. 1321–1327, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. J. J. Freiberger, “Utility of hyperbaric oxygen in treatment of bisphosphonate-related osteonecrosis of the jaws,” Journal of Oral and Maxillofacial Surgery, vol. 67, no. 5, pp. 96–106, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. P. Vescovi, E. Merigo, M. Meleti, and M. Manfredi, “Bisphosphonate-associated osteonecrosis (BON) of the jaws: a possible treatment?” Journal of Oral and Maxillofacial Surgery, vol. 64, no. 9, pp. 1460–1462, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. P. Vescovi, E. Merigo, M. Manfredi et al., “Nd:YAG laser biostimulation in the treatment of bisphosphonate-associated osteonecrosis of the jaw: clinical experience in 28 cases,” Photomedicine and Laser Surgery, vol. 26, no. 1, pp. 37–46, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Scoletta, P. G. Arduino, L. Reggio, P. Dalmasso, and M. Mozzati, “Effect of low-level laser irradiation on bisphosphonate-induced osteonecrosis of the jaws: preliminary results of a prospective study,” Photomedicine and Laser Surgery, vol. 28, no. 2, pp. 179–184, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. U. Romeo, A. Galanakis, C. Marias et al., “Observation of pain control in patients with bisphosphonate-induced osteonecrosis using low level laser therapy: preliminary results,” Photomedicine and Laser Surgery, vol. 29, no. 7, pp. 447–452, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. S. L. Engroff and D. D. Kim, “Treating bisphosphonate osteonecrosis of the jaws: is there a role for resection and vascularized reconstruction?” Journal of Oral and Maxillofacial Surgery, vol. 65, no. 11, pp. 2374–2385, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. R. Seth, N. D. Futran, D. S. Alam, and P. D. Knott, “Outcomes of vascularized bone graft reconstruction of the mandible in bisphosphonate-related osteonecrosis of the jaws,” Laryngoscope, vol. 120, no. 11, pp. 2165–2171, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. R. E. Marx, “Reconstruction of defects caused by bisphosphonate-induced osteonecrosis of the jaws,” Journal of Oral and Maxillofacial Surgery, vol. 67, no. 5, supplement, pp. 107–119, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. E. Merigo, M. Manfredi, M. Meleti et al., “Bone necrosis of the jaws associated with the use of bisphosphonates (pamidronate and zoledronate): a report of 29 cases,” Acta Bio Medica, vol. 77, no. 2, pp. 109–117, 2006. View at Google Scholar
  21. S. B. Pérez, M. V. Barreo, M. S. Hernàndez, M. Knezevic, J. M. Navarro, and J. R. Millares, “Bisphosphonate-associated osteonecrosis of the jaw. A proposal for conservative treatment,” Medicina Oral Patologia Oral y Cirugia Bucal, vol. 13, no. 12, pp. E770–E773, 2008. View at Google Scholar
  22. J. V. Bagan, Y. Jimenez, J. M. Diaz et al., “Osteonecrosis of the jaws in intravenous bisphosphonate use: proposal for a modification of the clinical classification,” Oral Oncology, vol. 45, no. 7, pp. 645–646, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. F. Wilde, M. Heufelder, K. Winter et al., “The role of surgical therapy in the management of intravenous bisphosphonates-related osteonecrosis of the jaw,” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, vol. 111, no. 2, pp. 153–163, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. R. E. Marx, J. E. Cillo Jr., and J. J. Ulloa, “Oral bisphosphonate-induced osteonecrosis: risk factors, prediction of risk using serum CTX testing, prevention, and treatment,” Journal of Oral and Maxillofacial Surgery, vol. 65, no. 12, pp. 2397–2410, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. F. Lumachi, D. A. Santeufemia, A. Del Conte et al., “Carboxy-terminal telopeptide (CTX) and amino-terminal propeptide (PINP) of type I collagen as markers of bone metastases in patients with non-small cell lung cancer,” Anticancer Research, vol. 33, no. 6, pp. 2593–2596, 2013. View at Google Scholar
  26. J. V. Bagan, Y. Jiménez, D. Gómez, R. Sirera, R. Poveda, and C. Scully, “Collagen telopeptide (serum CTX) and its relationship with the size and number of lesions in osteonecrosis of the jaws in cancer patients on intravenous bisphosphonates,” Oral Oncology, vol. 44, no. 11, pp. 1088–1089, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. S. Lehrer, A. Montazem, L. Ramanathan et al., “Normal serum bone markers in bisphosphonate-induced osteonecrosis of the jaws,” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, vol. 106, no. 3, pp. 389–391, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. T. S. Lazarovici, S. Mesilaty-Gross, I. Vered et al., “Serologic bone markers for predicting development of osteonecrosis of the jaw in patients receiving bisphosphonates,” Journal of Oral and Maxillofacial Surgery, vol. 68, no. 9, pp. 2241–2247, 2010. View at Google Scholar · View at Scopus
  29. K. E. Fleisher, G. Welch, S. Kottal, R. G. Craig, D. Saxena, and R. S. Glickman, “Predicting risk for bisphosphonate-related osteonecrosis of the jaws: CTX versus radiographic markers,” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, vol. 110, no. 4, pp. 509–516, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. A. Wutzl, S. Pohl, I. Sulzbacher et al., “Factors influencing surgical treatment of bisphosphonate-related osteonecrosis of the jaws,” Head and Neck, vol. 34, no. 2, pp. 194–200, 2012. View at Publisher · View at Google Scholar · View at Scopus
  31. L. Gallego and L. Junquera, “Consequence of therapy discontinuation in bisphosphonate-associated osteonecrosis of the jaws,” The British Journal of Oral and Maxillofacial Surgery, vol. 47, no. 1, pp. 67–68, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. T. Mawatari, “Bisphosphonates (BP) and osteonecrosis of the jaws; continuous treatment with Bisphosphonates should be considered,” Clinical Calcium, vol. 20, no. 11, pp. 1743–1747, 2010. View at Google Scholar · View at Scopus
  33. M. M. Curi, G. S. I. Cossolin, D. H. Koga et al., “Bisphosphonate-related osteonecrosis of the jaws—an initial case series report of treatment combining partial bone resection and autologous platelet-rich plasma,” Journal of Oral and Maxillofacial Surgery, vol. 69, no. 9, pp. 2465–2472, 2011. View at Publisher · View at Google Scholar · View at Scopus
  34. P. Vescovi and S. Nammour, “Bisphosphonate-related osteonecrosis of the jaw (BRONJ) therapy. A critical review,” Minerva Stomatologica, vol. 59, no. 4, pp. 181–213, 2010. View at Google Scholar · View at Scopus
  35. P. Rugani, S. Acham, A. Truschnegg, B. Obermayer-Pietsch, and N. Jakse, “Bisphosphonate-associated osteonecrosis of the jaws: surgical treatment with ErCrYSGG-laser. Case report,” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, vol. 110, no. 6, pp. e1–e6, 2010. View at Publisher · View at Google Scholar · View at Scopus
  36. P. Vescovi, M. Manfredi, E. Merigo et al., “Surgical approach with Er: YAG laser on osteonecrosis of the jaws (ONJ) in patients under bisphosphonate therapy (BPT),” Lasers in Medical Science, vol. 25, no. 1, pp. 101–113, 2010. View at Publisher · View at Google Scholar · View at Scopus
  37. P. Vescovi, E. Merigo, M. Manfredi et al., “Surgical treatment of maxillary osteonecrosis due to bisphosphonates using an Er:YAG (2940 nm) laser. Discussion of 17 clinical cases,” Revue Belge de Médecine Dentaire, vol. 64, no. 2, pp. 87–95, 2009. View at Google Scholar · View at Scopus
  38. F. Angiero, C. Sannino, R. Borloni, R. Crippa, S. Benedicenti, and G. E. Romanos, “Osteonecrosis of the jaws caused by bisphosphonates: evaluation of a new therapeutic approach using the Er:YAG laser,” Lasers in Medical Science, vol. 24, no. 6, pp. 849–856, 2009. View at Publisher · View at Google Scholar · View at Scopus
  39. S. Stübinger, J. Dissmann, N. C. Pinho, B. Saldamli, O. Seitz, and R. Sader, “A preliminary report about treatment of bisphosphonate related osteonecrosis of the jaw with Er:YAG laser ablation,” Lasers in Surgery and Medicine, vol. 41, no. 1, pp. 26–30, 2009. View at Publisher · View at Google Scholar · View at Scopus