Table of Contents Author Guidelines Submit a Manuscript
International Journal of Dentistry
Volume 2014, Article ID 192320, 5 pages
http://dx.doi.org/10.1155/2014/192320
Review Article

Bisphosphonate-Related Osteonecrosis of the Jaw: A Review of the Literature

1Department of Oral and Maxillofacial Surgery, Piracicaba Dental School, P.O. Box 52, University of Campinas (UNICAMP), 13414-903 Piracicaba, SP, Brazil
2Department of Dental Radiology, Piracicaba Dental School, P.O. Box 52, University of Campinas (UNICAMP), 13414-903 Piracicaba, SP, Brazil
3Department of Prosthesis and Periodontology, Piracicaba Dental School, P.O. Box 52, University of Campinas (UNICAMP), 13414-903 Piracicaba, SP, Brazil

Received 21 February 2014; Accepted 9 April 2014; Published 28 April 2014

Academic Editor: Giuliano Ascani

Copyright © 2014 Eder Alberto Sigua-Rodriguez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Bisphosphonates (BPs) are a class of drugs used to treat osteoporosis and malignant bone metastasis. BPs show high binding capacity to the bone matrix, especially in sites of active bone metabolism. The American Society for Bone and Mineral Research defines BRONJ as “an area of exposed bone in the maxillofacial region that has not healed within 8 weeks after identification by a healthcare provider in a patient who is receiving or has been exposed to a bisphosphonate and has not had radiation therapy to the craniofacial region.” Bisphosphonate-related osteonecrosis of the jaw (BRONJ) can adversely affect quality of life, as it may produce significant morbidity. The American Association of Oral and Maxillofacial Surgeons (AAOMS) considers as vitally important that information on BRONJ be disseminated to other dental and medical specialties. The purpose of this work is to offer a perspective on how dentists should manage patients on BPs, to show the benefits of accurately diagnosing BRONJ, and to present diagnostic aids and treatments strategies for the condition.