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International Journal of Dentistry
Volume 2015, Article ID 104812, 9 pages
http://dx.doi.org/10.1155/2015/104812
Research Article

Oral Lesions Induced by Chronic Khat Use Consist Essentially of Thickened Hyperkeratinized Epithelium

1Department of Maxillofacial Surgery, Oral Medicine, Pathology and Radiology, School of Dentistry, Moi University, P.O. Box 4606, Eldoret 30100, Kenya
2Department of Oral Biology, Anatomy, Physiology and Biochemistry, School of Dentistry, Moi University, P.O. Box 4606, Eldoret 30100, Kenya

Received 28 May 2015; Revised 25 August 2015; Accepted 2 September 2015

Academic Editor: Adriano Loyola

Copyright © 2015 Ochiba Mohammed Lukandu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. El-Menyar, A. Mekkodathil, H. Al-Thani, and A. Al-Motarreb, “Khat use: history and heart failure,” Oman Medical Journal, vol. 30, no. 2, pp. 77–82, 2015. View at Publisher · View at Google Scholar
  2. K. A. Sheikh, M. El-setouhy, U. Yagoub, R. Alsanosy, and Z. Ahmed, “Khat chewing and health related quality of life: cross-sectional study in Jazan region, Kingdom of Saudi Arabia,” Health and Quality of Life Outcomes, vol. 12, no. 1, article 44, 2014. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Al-Habori, “The potential adverse effects of habitual use of Catha edulis (khat),” Expert Opinion on Drug Safety, vol. 4, no. 6, pp. 1145–1154, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. T. M. Al-Qirim, M. Shahwan, K. R. Zaidi, Q. Uddin, and N. Banu, “Effect of khat, its constituents and restraint stress on free radical metabolism of rats,” Journal of Ethnopharmacology, vol. 83, no. 3, pp. 245–250, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. F. A. Sawair, A. Al-Mutwakel, K. Al-Eryani et al., “High relative frequency of oral squamous cell carcinoma in Yemen: qat and tobacco chewing as its aetiological background,” International Journal of Environmental Health Research, vol. 17, no. 3, pp. 185–195, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. A. M. Feyissa and J. P. Kelly, “A review of the neuropharmacological properties of khat,” Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 32, no. 5, pp. 1147–1166, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. S. W. Toennes, S. Harder, M. Schramm, C. Niess, and G. F. Kauert, “Pharmacokinetics of cathinone, cathine and norephedrine after the chewing of khat leaves,” British Journal of Clinical Pharmacology, vol. 56, no. 1, pp. 125–130, 2003. View at Publisher · View at Google Scholar · View at Scopus
  8. A. Astatkie, M. Demissie, Y. Berhane, and A. Worku, “Oral symptoms significantly higher among long-term khat (Catha edulis) user university students in Ethiopia,” Epidemiology and Health, vol. 37, Article ID e2015009, 2015. View at Publisher · View at Google Scholar
  9. A. A. Ali, “Qat Habit in Yemen society: a causative factor for oral periodontal diseases,” International Journal of Environmental Research and Public Health, vol. 4, no. 3, pp. 243–247, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. F. Kassie, F. Darroudi, M. Kundi, R. Schulte-Hermann, and S. Knasmüller, “Khat (Catha edulis) consumption causes genotoxic effects in humans,” International Journal of Cancer, vol. 92, no. 3, pp. 329–332, 2001. View at Publisher · View at Google Scholar · View at Scopus
  11. A. A. Ali, A. K. Al-Sharabi, J. M. Aguirre, and R. Nahas, “A study of 342 oral keratotic white lesions induced by qat chewing among 2500 Yemeni,” Journal of Oral Pathology and Medicine, vol. 33, no. 6, pp. 368–372, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Gorsky, J. B. Epstein, H. Levi, and N. Yarom, “Oral white lesions associated with chewing khat,” Tobacco Induced Diseases, vol. 2, no. 3, pp. 145–150, 2004. View at Publisher · View at Google Scholar
  13. N. Yarom, J. Epstein, H. Levi, D. Porat, E. Kaufman, and M. Gorsky, “Oral manifestations of habitual khat chewing: a case-control study,” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, vol. 109, no. 6, pp. e60–e66, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. A. A. Ali, “Histopathologic changes in oral mucosa of Yemenis addicted to water-pipe and cigarette smoking in addition to takhzeen al-qat,” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, vol. 103, no. 3, pp. e55–e59, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. H. G. E. Ahmed, A. S. A. Omer, and S. A. Abd Algaffar, “Cytological study of exfoliative buccal mucosal cells of Qat chewers in Yemen,” Diagnostic Cytopathology, vol. 39, no. 11, pp. 796–800, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. H. E. Soufi, M. Kameswaran, and T. Malatani, “Khat and oral cancer,” Journal of Laryngology and Otology, vol. 105, no. 8, pp. 643–645, 1991. View at Publisher · View at Google Scholar · View at Scopus
  17. A. H. Nasr and M. L. Khatri, “Head and neck squamous cell carcinoma in Hajjah, Yemen,” Saudi Medical Journal, vol. 21, no. 6, pp. 565–568, 2000. View at Google Scholar · View at Scopus
  18. A. A. Ali, A. K. Al-Sharabi, and J. M. Aguirre, “Histopathological changes in oral mucosa due to takhzeen al-qat: a study of 70 biopsies,” Journal of Oral Pathology and Medicine, vol. 35, no. 2, pp. 81–85, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. E. Stucken, J. Weissman, and J. H. Spiegel, “Oral cavity risk factors: experts' opinions and literature support,” Journal of Otolaryngology—Head & Neck Surgery, vol. 39, no. 1, pp. 76–89, 2010. View at Google Scholar · View at Scopus
  20. F. Carvalho, “The toxicological potential of khat,” Journal of Ethnopharmacology, vol. 87, no. 1, pp. 1–2, 2003. View at Publisher · View at Google Scholar · View at Scopus
  21. N. N. Al-Hebshi and N. Skaug, “Khat (Catha edulis)—an updated review,” Addiction Biology, vol. 10, no. 4, pp. 299–307, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. O. M. Lukandu, E. Neppelberg, O. K. Vintermyr, A. C. Johannessen, and D. E. Costea, “Khat alters the phenotype of in vitro-reconstructed human oral mucosa,” Journal of Dental Research, vol. 89, no. 3, pp. 270–275, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Prestin, S. I. Rothschild, C. S. Betz, and M. Kraft, “Measurement of epithelial thickness within the oral cavity using optical coherence tomography,” Head and Neck, vol. 34, no. 12, pp. 1777–1781, 2012. View at Publisher · View at Google Scholar · View at Scopus