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International Journal of Dentistry
Volume 2015, Article ID 283465, 5 pages
Research Article

Quantitative Analysis of Salivary TNF-α in Oral Lichen Planus Patients

Department of Oral Medicine & Radiology, Faculty of Dental Sciences, Sri Ramachandra University, Porur, Chennai 600116, India

Received 26 January 2015; Revised 25 February 2015; Accepted 26 February 2015

Academic Editor: Francesco Carinci

Copyright © 2015 T. Malarkodi and S. Sathasivasubramanian. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. The aim of this study was to quantitatively evaluate the salivary tumor necrosis factor-alpha (TNF-α) level in oral lichen planus patients and to compare the levels of TNF-α between saliva and serum of OLP and controls. Methods. Serum and whole saliva from 30 patients with active lesions of oral lichen planus (OLP) and 30 healthy persons were investigated for the presence of TNF-α by enzyme immunoassay. Student’s independent t-test and two-sample binomial proportion test were used to calculate significance of the mean values of TNF-alpha in serum and saliva and to determine the proportions of the detected and nondetected samples in both groups. Results. Proportion of detection and the mean of detectability between saliva and serum of Group B show an almost equal value, which suggests that saliva can be a good alternate to serum to analyze TNF-α in oral lichen planus patients.