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International Journal of Dentistry
Volume 2017, Article ID 1914073, 9 pages
Review Article

Genetic Factors and the Risk of Periodontitis Development: Findings from a Systematic Review Composed of 13 Studies of Meta-Analysis with 71,531 Participants

1Laboratory of Analysis and Histological Processing (LAPHIS), Federal University of Piaui, Parnaiba, PI, Brazil
2Postgraduate Program in Biomedical Sciences, Federal University of Piaui, Parnaiba, PI, Brazil
3Postgraduate Program in Biotechnology, Federal University of Piaui, Parnaiba, PI, Brazil
4Postgraduate Program in Dentistry, Federal University of Piaui, Teresina, PI, Brazil

Correspondence should be addressed to Daniel Fernando Pereira Vasconcelos; rb.ude.ipfu@solecnocsav

Received 2 December 2016; Revised 28 February 2017; Accepted 30 March 2017; Published 26 April 2017

Academic Editor: Tommaso Lombardi

Copyright © 2017 Maélson Klever da Silva et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. This work aimed to synthesize the results of recent meta-analysis focusing on polymorphism in inflammatory mediators and its relation with the risk of periodontitis development. Materials and Methods. A systematic search was conducted using databases for publications prior to October 2016. Three examiners extracted data from articles with a clear association between polymorphisms in the inflammatory mediator gene and the development of periodontitis through meta-analysis using the fixed or randomized statistical models to calculate the Odds Ratio with values of considered significant. Results. A total of 13 meta-analysis articles with 25 polymorphisms in seven interleukins (IL-1A, IL-1B, IL-4, IL-6, IL-8, IL-10, and IL-18), three cellular receptors (Fcγ receptors: FCGR2A, FCGR3A, and FCGR3B), and five inflammatory mediators (COX-2, MMP-2, MMP-3, MMP-8, and MMP-9), with a total of 71,531 participants, approaching different classifications of the disease. Conclusion. The study demonstrated that polymorphisms in the IL-1A, IL-1B, IL-6, IL-10, MMP-3 (chronic form), and MMP-9 (chronic form) polymorphisms were significantly associated with the risk of developing periodontitis, whereas other polymorphisms in the IL-4, IL-8, IL-18, Fcγ, COX-2, MMP-2, MMP-3 (aggressive), MMP-8, and MMP-9 (aggressive) polymorphisms had no significant association with risk of developing periodontitis.