International Journal of Dentistry / 2017 / Article / Tab 2 / Review Article
Genetic Factors and the Risk of Periodontitis Development: Findings from a Systematic Review Composed of 13 Studies of Meta-Analysis with 71,531 Participants Table 2 Statistical characteristics and results about heterogeneity value of the studies in meta-analysis and included in systematic search.
Med Author and reference Polymorphism I 2 (%)Statistical model used Periodontitis classification IL-1A Wang et al. [18 ] −889 C/T 28.86 P > 0.05FE Aggressive Silva et al. [15 ] −889 C/T 15 P = 0.28FE Chronic IL-1B Zeng et al. [19 ] −511 C/T 79.54 P < 0.05RE Chronic Chen et al. [20 ] +3954 C/T 62.2 P < 0.05RE Aggressive Ma et al. [21 ] +3954 C/T 81% P < 0.05RE Chronic IL-4 Yan et al. [17 ] −590 C/T 90.4 P < 0.05P < 0.05P < 0.05RE Aggressive/chronic IL-6 Song et al. [22 ] −174 G/C 64.9 P < 0.05P < 0.05RE Aggressive/chronic IL-8 Chen et al. [23 ] −251 A/T NR P < 0.001P = 0.40RE Aggressive/chronic IL-10 Zhong et al. [24 ] −1082 A/G 23.9 P = 0.26P = 0.20P = 0.04FE Aggressive/chronic IL-18 Li et al. [25 ] −607 A/C 38.1 P = 0.19P = 0.97FE Aggressive/chronic FCGR2A Song and Lee [10 ] R131H 5.95 P = 0.45P = 0.49P = 0.48P = 0.56P = 0.001FE Chronic COX-2 Jiang et al. [8 ] −765G/C 95.4 P < 0.05P < 0.05P < 0.05P > 0.05RE Chronic MMP-2 Weng et al. [11 ] −753 C/T 0 P > 0.05P > 0.05P = 0.17P > 0.05P < 0.05P < 0.001P = 0.49FE Chronic
Med: inflammatory mediator, IL: interleukins, FGCGR: receptor Fcγ , COX-2: cyclooxygenase 2, MMP: matrix metalloproteinase, I 2 : chi-squared based Q statistic test, NR: not reported, NA: not applicable, and P < 0.05: statistic value significant.
