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International Journal of Dentistry
Volume 2017 (2017), Article ID 1965697, 9 pages
Research Article

Estimation of Antioxidant Levels in Saliva and Serum of Chronic Periodontitis Patients with and without Ischemic Heart Disease

1Department of Periodontics, A.B. Shetty Memorial Institute of Dental Sciences, Nitte University, Deralakatte, Mangalore, Karnataka 575018, India
2Department of Biochemistry, K.S. Hegde Medical Academy, Nitte University, Deralakatte, Mangalore, Karnataka 575018, India

Correspondence should be addressed to Anahita Punj

Received 27 December 2016; Revised 13 March 2017; Accepted 31 May 2017; Published 11 July 2017

Academic Editor: Gilberto Sammartino

Copyright © 2017 Anahita Punj et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To investigate whether there is a relationship between periodontitis and ischemic heart disease by estimation of total antioxidant status in saliva and serum. Materials and Methods. A total of 80 samples were collected and divided equally into 4 groups of healthy controls, chronic periodontitis patients, ischemic heart disease patients with periodontitis, and ischemic heart disease patients without periodontitis. Saliva and venous blood samples were collected and analyzed for levels of total antioxidant capacity, superoxide dismutase, glutathione peroxidase, and catalase. Results. There were significant () differences in the mean serum levels of total antioxidant capacity (), superoxide dismutase (), glutathione peroxidase (), and catalase () within the 4 groups, whereas the mean salivary levels were significant only for glutathione peroxidase (). Both of these serum and salivary antioxidant levels were lower in disease groups of IHD + CP, IHD + H, and CP as compared to healthy controls, with different patterns. Conclusion. Antioxidant capacity is significantly hampered in chronic periodontitis and ischemic heart disease patients with or without periodontitis as compared to healthy controls. The salivary and serum antioxidants may not follow the same increase or decrease as a result of increased oxidant stress due to disease.