Table of Contents Author Guidelines Submit a Manuscript
International Journal of Dentistry
Volume 2017, Article ID 7034390, 6 pages
https://doi.org/10.1155/2017/7034390
Clinical Study

Relative Efficacy of Quercetin Compared with Benzydamine Hydrochloride in Minor Aphthae: A Prospective, Parallel, Double Blind, Active Control, Preliminary Study

1Oral Medicine and Radiology, Private Practice, New Delhi, India
2Oral Medicine and Radiology, College of Dental Sciences, Davangere, India
3Oral Medicine and Radiology, A. J. Institute of Dental Sciences, Mangalore, India

Correspondence should be addressed to Dhanya S. Rao; moc.liamg@12oaraynahd

Received 26 December 2016; Revised 17 July 2017; Accepted 24 September 2017; Published 13 November 2017

Academic Editor: Manal Awad

Copyright © 2017 Maitreyi Pandya et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. S. Vijayabala, A. N. Kalappanavar, R. G. Annigeri, R. Sudarshan, and S. S. Shettar, “Single application of topical doxycycline hyclate in the management of recurrent aphthous stomatitis,” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, vol. 116, no. 4, pp. 440–446, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. J. A. Ship, E. M. Chavez, P. A. Doerr, B. S. Henson, and M. Sarmadi, “Recurrent aphthous stomatitis,” Quintessence International, vol. 31, no. 2, pp. 95–112, 2000. View at Google Scholar · View at Scopus
  3. S. Yunus, K. Basal, and O. Perihan, “Assessment of salivary serum antioxidant vitamins lipid peroxidation in patients with recurrent aphthous ulceration,” The Tohoku Journal of Experimental Medicine, vol. 206, pp. 305–312, 2005. View at Google Scholar
  4. M. A. Mostafa and M. A. Ibrahem, “Management of aphthous ulceration with topical quercetin,” Cairo Dental Journal, vol. 25, no. 1, p. 15, 2009. View at Google Scholar
  5. M. Harwood, B. Danielewska-Nikiel, J. F. Borzelleca, G. W. Flamm, G. M. Williams, and T. C. Lines, “A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties,” Food and Chemical Toxicology, vol. 45, no. 11, pp. 2179–2205, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. P. Lakhanpal and D. K. Rai, “Quercetin: a versatile flavonoid,” Internet Journal of Medical Update, vol. 2, no. 2, pp. 22–37, 2007. View at Publisher · View at Google Scholar
  7. A. Gurel, H. C. Altinyazar, M. Unalacak, F. Armutcu, and R. Koca, “Purine catabolic enzymes and nitric oxide in patients with recurrent aphthous ulceration,” Oral Diseases, vol. 13, no. 6, pp. 570–574, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Dogan, C. Yilmaz, H. Caksen, and A. S. Guven, “A case of benzydamine HCL intoxication,” Eastern Journal of Medicine, vol. 11, pp. 26–28, 2006. View at Google Scholar
  9. E. Riboldi, G. Frascaroli, P. Transidico et al., “Benzydamine inhibits monocyte migration and MAPK activation induced by chemotactic agonists,” British Journal of Pharmacology, vol. 140, no. 2, pp. 377–383, 2003. View at Publisher · View at Google Scholar · View at Scopus
  10. N. H. Fanaki and M. A. El-Nakeeb, “Antimicrobial activity of benzydamine, a non-steroid anti-inflammatory agent,” Journal of Chemotherapy, vol. 4, no. 6, pp. 347–352, 1992. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Valijan, “Pain relief after tonsillectomy Effect of benzydamine hydrochloride spray on postoperative pain relief after tonsillectomy,” Anaesthesia, vol. 44, no. 12, pp. 990-991, 1989. View at Publisher · View at Google Scholar · View at Scopus
  12. T. F. Meiller, M. J. Kutcher, C. D. Overholser, C. Niehaus, L. G. DePaola, and M. A. Siegel, “Effect of an antimicrobial mouthrinse on recurrent aphthous ulcerations,” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, vol. 72, no. 4, pp. 425–429, 1991. View at Publisher · View at Google Scholar · View at Scopus
  13. A. Khandwala, R. G. Van Inwegen, and M. C. Alfano, “5% amlexanox oral paste, a new treatment for recurrent minor aphthous ulcers: I. Clinical demonstration of acceleration of healing and resolution of pain,” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, vol. 83, no. 2, pp. 222–230, 1997. View at Publisher · View at Google Scholar · View at Scopus
  14. S. S. Natah, Y. T. Konttinen, N. S. Enattah, N. Ashammakhi, K. A. Sharkey, and R. Häyrinen-Immonen, “Recurrent aphthous ulcers today: a review of the growing knowledge,” International Journal of Oral and Maxillofacial Surgery, vol. 33, no. 3, pp. 221–234, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. G. Roopashri, K. Jayanthi, and R. Guruprasad, “Efficacy of benzydamine hydrochloride, chlorhexidine, and povidone iodine in the treatment of oral mucositis among patients undergoing radiotherapy in head and neck malignancies: A drug trail,” Contemporary Clinical Dentistry, vol. 2, no. 1, pp. 8–12, 2011. View at Publisher · View at Google Scholar
  16. S. Saxena, “Assessment of plasma and salivary antioxidant status in patients with recurrent aphthous stomatitis,” RSBO, vol. 8, no. 3, pp. 261–265, 2011. View at Publisher · View at Google Scholar
  17. C. Scully and S. Porter, “Oral mucosal disease: recurrent aphthous stomatitis,” British Journal of Oral and Maxillofacial Surgery, vol. 46, no. 3, pp. 198–206, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. R. Kaur, D. Singh, and K. Chopra, “Participation of α2 receptors in the antinociceptive activity of quercetin,” Journal of Medicinal Food, vol. 8, no. 4, pp. 529–532, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Hämäläinen, R. Nieminen, P. Vuorela, M. Heinonen, and E. Moilanen, “Anti-inflammatory effects of flavonoids: Genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-κB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-κB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages,” Mediators of Inflammation, vol. 2007, Article ID 45673, 10 pages, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. http://examine.com/supplements/Quercetin/#thingstoknow.
  21. R. W. Matthews, C. M. Scully, B. G. H. Levers, and W. S. Hislop, “Clinical evaluation of benzydamine, chlorhexidine, and placebo mouthwashes in the management of recurrent aphthous stomatitis,” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, vol. 63, no. 2, pp. 189–191, 1987. View at Publisher · View at Google Scholar · View at Scopus