Variation of Energy in Photobiomodulation for the Control of Radiotherapy-Induced Oral Mucositis: A Clinical Study in Head and Neck Cancer Patients

Table 1

Protocols of laser irradiation (adapted from Zecha et al. [11]).

	Protocol
	Group 0.25 J	Group 1.0 J
Source (laser device)	Indium gallium arsenide phosphide semiconductor laser	Indium gallium arsenide phosphide semiconductor laser
Wavelength	660 nm (visible red)	660 nm (visible red)
Power	25 mW	100 mW
Beam area	4 mm^2	3 mm^2
Energy (radiation)	0.25 J	1.0 J
Time	10 s	10 s
Dosage (fluence or energy density)	6.3 J/cm^2	33 J/cm^2
Operating mode	Continuous wave	Continuous wave
Physical relationship to the organ	Intraoral, direct contact with oral mucosa	Intraoral, direct contact with oral mucosa
Schedule	Concomitant to radiotherapy	Concomitant to radiotherapy

Twin Flex Evolution, MM Optics Ltda, São Carlos, São Paulo, Brazil; Laser Duo, MM Optics Ltda, São Carlos, São Paulo, Brazil.