International Journal of Dentistry

International Journal of Dentistry / 2018 / Article

Corrigendum | Open Access

Volume 2018 |Article ID 5656189 |

Jefferson Soares de Oliveira, Moara e Silva Conceição Pinto, Lucas de Araújo de Bastos Santana, Antonione Santos Bezerra Pinto, David di Lenardo, Daniel Fernando Pereira Vasconcelos, "Corrigendum to “Biological Effects of Medicinal Plants on Induced Periodontitis: A Systematic Review”", International Journal of Dentistry, vol. 2018, Article ID 5656189, 5 pages, 2018.

Corrigendum to “Biological Effects of Medicinal Plants on Induced Periodontitis: A Systematic Review”

Received03 Dec 2017
Accepted10 Dec 2017
Published27 Feb 2018

In the article titled “Biological Effects of Medicinal Plants on Induced Periodontitis: A Systematic Review” [1], it is stated in Table 1 that Hosadurga et al., cited as references 4 and 16 in the article, examined the anti-inflammatory action of 2% curcumin and Ocimum sanctum gel in a separate model. However, the authors of these articles informed us that they studied the gingival index, which is an indirect measure of inflammation in the gingival tissues. They also assessed the antimicrobial activity but did not publish the data, since they encountered a problem with the solubility and did not get a well-defined clear zone of inhibition. Corrected information about references [4] and [16] in Table 1 is as follows.

Plant speciesPlant materialRoute of administrationAnimal used (gender)Type of induction/time of analysisAntibacterial effect1Bone loss/method2Anti-inflammatory activity3Reference

Panax notoginseng and Rehmannia radisMixture of extracts (9 : 1 weight)OralRattus norvegicus (male)Injecting E. coli endotoxin (LPS)/28 daysNot evaluatedReduced ABC/µCTReduced the in vitro release of TNF-α from human monocytic cells and hGF cellsAlmeida et al. [2]
Ocimum sanctumTulsi extractTopicalRattus norvegicus (male and female)Silk ligature/9 daysNot evaluatedNot reduced ABC/StereoPresented anti-inflammatory activity in a separate model (paw edema)Hosadurga et al. [4]
Scutellaria baicalensisBaicalinOralRattus norvegicus (male)Nylon ligature/7 daysNot evaluatedReduced ABC/histologyNot evaluatedCai et al. [6]
Rhizoma coptidis, Hydrastis canadensis, and Cortex phellodendriBerberineOralRattus norvegicus (male)Silk ligature/8 daysNot evaluatedReduced ABC/µCTNot evaluatedTu et al. [7]
Cucurbita pepo, Mentha piperita, Crataegus spp., Rosmarinus officinalis, Capsicum annuum, Achillea millefoliumLongoVital®OralRattus norvegicus (male and female)Injecting A. viscosus and P. gingivalis/63 daysNot evaluatedReduced ABC/RadioNot evaluatedKlausen et al. [8]
Mangifera indicaMangiferin (Sigma-Aldrich Co.)OralRattus norvegicus (male)Cotton ligature/1, 4, 7 daysNot evaluatedReduced ABC/histologyInhibited COX-2 expression, the rolling, and adhesion of leukocytes in the periodontal tissueCarvalho et al. [9]
Curcuma longaCurcumin (Sigma-Aldrich Co.)GavageRattus norvegicus (male)Nylon ligature/30 daysNot evaluatedReduced ABC/histologyReduced the expression of TNF-α in gingival tissuesZhou et al. [10]
Magnolia officinalisMagnolol (Sigma-Aldrich Co.)OralRattus norvegicus (male)Silk ligature/9 daysIn vitro activity against P. gingivalis and A. actinomycetemcomitanReduced ABC/µCTInhibited neutrophil migration, MPO activity, and COX-2 and iNOS expression in gingival tissuesLu et al. [11]
Rhizoma drynariae and Rehmannia glutinosaBu-Shen-Gu-Chi-Wan (JiuZhiTang Pharmaceutical)OralRattus norvegicus (female)Injecting P. gingivalis and ligature/28 daysNot evaluatedImproved the mineral density of the bone/µCTReduced levels of IL-1β, TNF-α, and inflammatory cell infiltration in the periodontal tissuesYang et al. [12]
Pinus pinasterPycnogenol® (Tradepia Co.)OralBalb/c (male)Injecting P. gingivalis/34 daysAntibacterial activity against P. gingivalisReduced ABC/StereoNot evaluatedSugimoto et al. [13]
Vaccinium macrocarponAqueous extract containing tannin and phenolic compoundsOralMus musculus (female)Injecting P. gingivalis and F. nucleatum/42 daysAntiadhesive properties against P. gingivalis and F. nucleatum. Increased the phagocytosis of P. gingivalisNot evaluatedReduced in vivo levels of TNF-αPolak et al. [15]
Curcuma longaCurcuminTopicalRattus norvegicusSilk ligature/28 daysNot evaluatedDid not reduce ABC/StereoExhibited anti-inflammatory activity in a separate model (paw edema)Hosadurga et al. [16]
Camellia sinensisExtract containing catechinTopicalRattus norvegicus (male)Injecting E. coli (LPS) and S. griseus (proteases)/56 daysNot evaluatedDid not reduce ABC/histologyReduced inflammatory cell infiltration and levels of TNF-α in the periodontal lesionMaruyama et al. [19]
Spatholobus suberectusAqueous extractOralMus musculus (male)Injecting P. gingivalis/42 daysIn vitro antibacterial activity against P. gingivalisReduced ABC/StereoNot evaluatedToyama et al. [20]
Carapa guianensisAndiroba oilOralRattus norvegicus (male)Cotton ligature/50 daysNot evaluatedDid not reduce ABC/histologyReduced the quantity of inflammatory cells in histologyCarmona et al. [21]
Protium heptaphyllumα-Amyrin and β-amyrinOralRattus norvegicus (male)Nylon ligature/1 dayNot evaluatedNot evaluatedReduced gingival TNF-α levels and MPO activityHolanda Pinto et al. [22]
Camellia sinensisExtract containing catechinOralRattus norvegicus (male)Nylon ligature/7, 14, 28 daysNot evaluatedReduced ABC/histologyReduced in vivo levels of TNF-αCho et al. [23]
Ipomoea albaMixture of dichloromethane and methanol extractTopicalRattus norvegicus (male)Cotton ligature/11 daysIn vitro antibacterial activity against S. mutans, S. and E. faecalisDid not reduce ABC/StereoNot evaluatedBarrella et al. [24]
Lippia sidoides and Myracroduon urundeuvaMixture of leaf essential oil and hydroalcoholic solution from barkTopicalRattus norvegicus (male)Nylon ligature/11 daysPrevented the growth of oral microorganisms from gingival tissueReduced ABC/histologyReduced MPO activity and inhibited TNF-α and IL-1β production in gingival tissueBotelho et al. [25]
Lippia sidoidesCarvacrolTopicalRattus norvegicus (male)Nylon ligature/11 daysPrevented the growth of oral microorganisms from gingival tissueReduced ABC/AFMReduced MPO activity in gingival tissueBotelho et al. [26]
Hypericum perforatumMethanolic extractOralRattus norvegicus (male)Silk ligature/8 daysNot evaluatedReduced ABC/StereoReduced inflammatory cell infiltration, vascular permeability, expression of NF-κB and MPO activity in gingivomucosal tissuePaterniti et al. [27]
Cordia verbenaeaEssential oilTopicalRattus norvegicus (male)Cotton ligature/11 daysReduced in vivo frequency of P. gingivalis and A. actinomycetemcomitansReduced ABC/histologyIncrement in the in vivo levels of IL-10Pimentel et al. [28]
Camellia sinensisExtract containing catechinTopicalRattus norvegicus (male)Injecting E. coli (LPS)/10 and 20 daysNot evaluatedReduced ABC/histologyReduced inflammatory cell infiltrationYoshinaga et al. [29]
Theobroma cacaoCocoa extract containing flavonoidsOralRattus norvegicus (male)Cotton ligature/28 daysNot evaluatedReduced ABC/histologyReduced/oxidized glutathione ratio and neutrophil infiltrationTomofuji et al. [30]
Mikania laevigataEthanol extractSubcutaneousRattus norvegicus (male)Nylon ligature/30 daysNot evaluatedReduced the furcation region/histologyReduced neutrophil accumulation in the gingival tissueBenatti et al. [31]
Pimpinella anisum, Illicium verum, Anethum foeniculumAnetholeIntraperitonealRattus norvegicus (male)Injecting E. coli (LPS)/10 daysNot evaluatedNot evaluatedReduced serum levels of IL-1β and TNF-αMoradi et al. [32]
Curcuma spp.Modified curcuminGavageRattus norvegicus (male)Injecting E. coli (LPS)/14 daysNot evaluatedReduced ABC/Stereo, and µCTReduced serum level of IL-1βElburki et al. [33]
Syringa vulgarisProduct of fermentationOralRattus norvegicus (male)Silk ligature/8 daysNot evaluatedReduced ABC/StereoReduced NF-κB and iNOS expression, MPO activity, and other inflammatory parameters in gingivomucosal tissuePaola et al. [34]
Ginkgo bilobaGinkgo biloba extractOralRattus norvegicus (male)Silk ligature/11 daysNot evaluatedReduced ABC/histologyNot evaluatedSezer et al. [35]
Curcuma spp.CurcuminGavageRattus norvegicus (male)Cotton ligature/15 daysNot evaluatedDid not reduce ABC/µCTReduced the inflammatory cell infiltrate to gingival tissueGuimarães et al. [36]

1Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitan, Streptococcus mutans, Streptococcus sanguinis, Enterococcus faecalis, and Fusobacterium nucleatum. 2ABC: alveolar bone crest, µCT: microcomputed tomography, AFM: atomic force microscopy, Stereo: stereomicroscopy, Radio: radiography. 3TNF-α: tumor necrosis factor α, hGF: hepatocyte growth factor, MPO: myeloperoxidase activity, IL-1β: interleukin-1 beta, IL-10: interleukin-10, NF-κB: nuclear factor kappa-β, COX-2: cyclooxygenase-2, and iNOS: inducible nitric oxide synthase.


  1. J. Soares de Oliveira, M. S. Conceição Pinto, L. A. B. Santana, A. S. B. Pinto, D. Lenardo, and D. F. P. Vasconcelos, “Biological effects of medicinal plants on induced periodontitis: a systematic review,” International Journal of Dentistry, vol. 2016, Article ID 3719879, 10 pages, 2016. View at: Publisher Site | Google Scholar

Copyright © 2018 Jefferson Soares de Oliveira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

More related articles

 PDF Download Citation Citation
 Download other formatsMore
 Order printed copiesOrder

Related articles