International Journal of Dentistry / 2018 / Article / Tab 1

Corrigendum

Corrigendum to “Biological Effects of Medicinal Plants on Induced Periodontitis: A Systematic Review”

Table 1

List of medicinal plants, experimental methods, and their biological effects on induced periodontitis.

Plant speciesPlant materialRoute of administrationAnimal used (gender)Type of induction/time of analysisAntibacterial effect1Bone loss/method2Anti-inflammatory activity3Reference

Panax notoginseng and Rehmannia radisMixture of extracts (9 : 1 weight)OralRattus norvegicus (male)Injecting E. coli endotoxin (LPS)/28 daysNot evaluatedReduced ABC/µCTReduced the in vitro release of TNF-α from human monocytic cells and hGF cellsAlmeida et al. [2]
Ocimum sanctumTulsi extractTopicalRattus norvegicus (male and female)Silk ligature/9 daysNot evaluatedNot reduced ABC/StereoPresented anti-inflammatory activity in a separate model (paw edema)Hosadurga et al. [4]
Scutellaria baicalensisBaicalinOralRattus norvegicus (male)Nylon ligature/7 daysNot evaluatedReduced ABC/histologyNot evaluatedCai et al. [6]
Rhizoma coptidis, Hydrastis canadensis, and Cortex phellodendriBerberineOralRattus norvegicus (male)Silk ligature/8 daysNot evaluatedReduced ABC/µCTNot evaluatedTu et al. [7]
Cucurbita pepo, Mentha piperita, Crataegus spp., Rosmarinus officinalis, Capsicum annuum, Achillea millefoliumLongoVital®OralRattus norvegicus (male and female)Injecting A. viscosus and P. gingivalis/63 daysNot evaluatedReduced ABC/RadioNot evaluatedKlausen et al. [8]
Mangifera indicaMangiferin (Sigma-Aldrich Co.)OralRattus norvegicus (male)Cotton ligature/1, 4, 7 daysNot evaluatedReduced ABC/histologyInhibited COX-2 expression, the rolling, and adhesion of leukocytes in the periodontal tissueCarvalho et al. [9]
Curcuma longaCurcumin (Sigma-Aldrich Co.)GavageRattus norvegicus (male)Nylon ligature/30 daysNot evaluatedReduced ABC/histologyReduced the expression of TNF-α in gingival tissuesZhou et al. [10]
Magnolia officinalisMagnolol (Sigma-Aldrich Co.)OralRattus norvegicus (male)Silk ligature/9 daysIn vitro activity against P. gingivalis and A. actinomycetemcomitanReduced ABC/µCTInhibited neutrophil migration, MPO activity, and COX-2 and iNOS expression in gingival tissuesLu et al. [11]
Rhizoma drynariae and Rehmannia glutinosaBu-Shen-Gu-Chi-Wan (JiuZhiTang Pharmaceutical)OralRattus norvegicus (female)Injecting P. gingivalis and ligature/28 daysNot evaluatedImproved the mineral density of the bone/µCTReduced levels of IL-1β, TNF-α, and inflammatory cell infiltration in the periodontal tissuesYang et al. [12]
Pinus pinasterPycnogenol® (Tradepia Co.)OralBalb/c (male)Injecting P. gingivalis/34 daysAntibacterial activity against P. gingivalisReduced ABC/StereoNot evaluatedSugimoto et al. [13]
Vaccinium macrocarponAqueous extract containing tannin and phenolic compoundsOralMus musculus (female)Injecting P. gingivalis and F. nucleatum/42 daysAntiadhesive properties against P. gingivalis and F. nucleatum. Increased the phagocytosis of P. gingivalisNot evaluatedReduced in vivo levels of TNF-αPolak et al. [15]
Curcuma longaCurcuminTopicalRattus norvegicusSilk ligature/28 daysNot evaluatedDid not reduce ABC/StereoExhibited anti-inflammatory activity in a separate model (paw edema)Hosadurga et al. [16]
Camellia sinensisExtract containing catechinTopicalRattus norvegicus (male)Injecting E. coli (LPS) and S. griseus (proteases)/56 daysNot evaluatedDid not reduce ABC/histologyReduced inflammatory cell infiltration and levels of TNF-α in the periodontal lesionMaruyama et al. [19]
Spatholobus suberectusAqueous extractOralMus musculus (male)Injecting P. gingivalis/42 daysIn vitro antibacterial activity against P. gingivalisReduced ABC/StereoNot evaluatedToyama et al. [20]
Carapa guianensisAndiroba oilOralRattus norvegicus (male)Cotton ligature/50 daysNot evaluatedDid not reduce ABC/histologyReduced the quantity of inflammatory cells in histologyCarmona et al. [21]
Protium heptaphyllumα-Amyrin and β-amyrinOralRattus norvegicus (male)Nylon ligature/1 dayNot evaluatedNot evaluatedReduced gingival TNF-α levels and MPO activityHolanda Pinto et al. [22]
Camellia sinensisExtract containing catechinOralRattus norvegicus (male)Nylon ligature/7, 14, 28 daysNot evaluatedReduced ABC/histologyReduced in vivo levels of TNF-αCho et al. [23]
Ipomoea albaMixture of dichloromethane and methanol extractTopicalRattus norvegicus (male)Cotton ligature/11 daysIn vitro antibacterial activity against S. mutans, S. and E. faecalisDid not reduce ABC/StereoNot evaluatedBarrella et al. [24]
Lippia sidoides and Myracroduon urundeuvaMixture of leaf essential oil and hydroalcoholic solution from barkTopicalRattus norvegicus (male)Nylon ligature/11 daysPrevented the growth of oral microorganisms from gingival tissueReduced ABC/histologyReduced MPO activity and inhibited TNF-α and IL-1β production in gingival tissueBotelho et al. [25]
Lippia sidoidesCarvacrolTopicalRattus norvegicus (male)Nylon ligature/11 daysPrevented the growth of oral microorganisms from gingival tissueReduced ABC/AFMReduced MPO activity in gingival tissueBotelho et al. [26]
Hypericum perforatumMethanolic extractOralRattus norvegicus (male)Silk ligature/8 daysNot evaluatedReduced ABC/StereoReduced inflammatory cell infiltration, vascular permeability, expression of NF-κB and MPO activity in gingivomucosal tissuePaterniti et al. [27]
Cordia verbenaeaEssential oilTopicalRattus norvegicus (male)Cotton ligature/11 daysReduced in vivo frequency of P. gingivalis and A. actinomycetemcomitansReduced ABC/histologyIncrement in the in vivo levels of IL-10Pimentel et al. [28]
Camellia sinensisExtract containing catechinTopicalRattus norvegicus (male)Injecting E. coli (LPS)/10 and 20 daysNot evaluatedReduced ABC/histologyReduced inflammatory cell infiltrationYoshinaga et al. [29]
Theobroma cacaoCocoa extract containing flavonoidsOralRattus norvegicus (male)Cotton ligature/28 daysNot evaluatedReduced ABC/histologyReduced/oxidized glutathione ratio and neutrophil infiltrationTomofuji et al. [30]
Mikania laevigataEthanol extractSubcutaneousRattus norvegicus (male)Nylon ligature/30 daysNot evaluatedReduced the furcation region/histologyReduced neutrophil accumulation in the gingival tissueBenatti et al. [31]
Pimpinella anisum, Illicium verum, Anethum foeniculumAnetholeIntraperitonealRattus norvegicus (male)Injecting E. coli (LPS)/10 daysNot evaluatedNot evaluatedReduced serum levels of IL-1β and TNF-αMoradi et al. [32]
Curcuma spp.Modified curcuminGavageRattus norvegicus (male)Injecting E. coli (LPS)/14 daysNot evaluatedReduced ABC/Stereo, and µCTReduced serum level of IL-1βElburki et al. [33]
Syringa vulgarisProduct of fermentationOralRattus norvegicus (male)Silk ligature/8 daysNot evaluatedReduced ABC/StereoReduced NF-κB and iNOS expression, MPO activity, and other inflammatory parameters in gingivomucosal tissuePaola et al. [34]
Ginkgo bilobaGinkgo biloba extractOralRattus norvegicus (male)Silk ligature/11 daysNot evaluatedReduced ABC/histologyNot evaluatedSezer et al. [35]
Curcuma spp.CurcuminGavageRattus norvegicus (male)Cotton ligature/15 daysNot evaluatedDid not reduce ABC/µCTReduced the inflammatory cell infiltrate to gingival tissueGuimarães et al. [36]

1Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitan, Streptococcus mutans, Streptococcus sanguinis, Enterococcus faecalis, and Fusobacterium nucleatum. 2ABC: alveolar bone crest, µCT: microcomputed tomography, AFM: atomic force microscopy, Stereo: stereomicroscopy, Radio: radiography. 3TNF-α: tumor necrosis factor α, hGF: hepatocyte growth factor, MPO: myeloperoxidase activity, IL-1β: interleukin-1 beta, IL-10: interleukin-10, NF-κB: nuclear factor kappa-β, COX-2: cyclooxygenase-2, and iNOS: inducible nitric oxide synthase.