Interleukin-1 Gene Variability and Plasma Levels in Czech Patients with Chronic Periodontitis and Diabetes Mellitus

Table 4

IL-1β plasma levels and polymorphisms in IL-1B and IL-1RN genes.

Genotypes	All groups ()	IL-1β levels (pg/mL), median (IQR)
IL-1B (+3953C/T)
CC	31 (51.7)	3.26 (2.57–5.43)
CT	26 (43.3)	3.26 (2.57–10.59)
TT	3 (5.0)	2.69 (2.57–9.88)
IL-1RN (VNTR)^§
LL	37 (61.7)	3.26 (2.57–10.24)
LS	17 (28.3)	3.85 (2.57–9.35)
SS	5 (8.3)	3.26 (2.63–6.79)

IQR = interquartile range. ^§Alleles with more than two repeat units were grouped together as IL-1RNL (“long” allele) and 2 repeat units were marked as IL-1RNS (“short” allele); genotypes are known only in 59 subjects. The Kruskal–Wallis ANOVA test was used to calculate significant differences.