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International Journal of Dentistry
Volume 2019, Article ID 9056590, 8 pages
https://doi.org/10.1155/2019/9056590
Research Article

Development and Formulation of the Experimental Dentifrice Based on Passiflora mollissima (Tumbo) with and without Fluoride Anion: Antibacterial Activity on Seven Antimicrobial Strains

1Professor of Stomatology School, Universidad Privada San Juan Bautista, Lima, Peru
2Department of Basic Sciences, Faculty of Health Sciences, Universidad Privada San Juan Bautista, Lima, Peru
3Department of Chemistry, Faculty of Health Sciences, Universidad Privada San Juan Bautista, Lima, Peru
4Stomatology School, Universidad Privada San Juan Bautista, Lima, Peru

Correspondence should be addressed to Frank Mayta-Tovalino; moc.liamg@0.2ocitsidatse

Received 15 February 2019; Revised 14 May 2019; Accepted 21 May 2019; Published 13 June 2019

Academic Editor: Alessandro Leite Cavalcanti

Copyright © 2019 Frank Mayta-Tovalino et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objectives. To develop and formulate a new experimental dentifrice with and without fluoride based on the peel and the fruit of the Passiflora mollissima (tumbo) and also to evaluate its antimicrobial activity against seven bacterial strains. Methods. The sample was calculated using the mean comparison formula, obtaining wells (n = 12) for each of the strains evaluated: S. mutans, E. faecalis, Actinomyces, Lactobacillus, C. albicans, S. sanguinis, and S. oralis. The antibacterial activity of the dentifrice was evaluated by the direct contact technique. Results. It was found that the highest antimicrobial activity was only present in pulp-based dentifrices against strains of S. mutans 21.0 ± 1.8, E. faecalis 16.3 ± 3.9, Actinomyces 22.1 ± 1.3, and Lactobacillus 21.0 ± 1.3. However, in comparison with other strains such as C. albicans, S. sanguinis, and S. oralis, the peel-based dendrifrice of Passiflora mollissima obtained the highest antimicrobial activity. Conclusion. The experimental dentifrice based on Passiflora mollissima had an antibacterial effect against the seven microbial strains during the first 24 and 48 hours.