|
| Author and year | Methods | Participants | Intervention | Outcomes | Conclusions |
| Study design | Follow-up | Country of study setting | Sample size | Mean age and gender | Materials used | Site of restoration | Renal | CNS | Social-behaviour. | Others |
|
| Bellinger et al., 2006 [24] | RCT | 5 years | USA | 534 | 7.9 years | Dispersed phase amalgam; composite resin | Posterior teeth | Urinary Hg; | IQ | NA | Hair Hg | Urinary Hg was significantly higher level in the amalgam group; no significant differences for other outcomes. |
| 287 M, 247 F | Urinary Albumin | Memory |
| | | Visuomotor |
|
| Bellinger et al., 2008 [35] | RCT | 5 years | USA | 534 | 7.9 years | Dispersed phase amalgam; composite resin | Posterior teeth | NA | NA | CBCL; BASC | NA | Amalgam group had significant improvement in “Total Problem Behaviour,” “Internalizing,” “Delinquent Behaviors,” “Activities,” and “Anxious/Depressed” domains (CBCL) and in “Personal adjustment” and “Emotional Symptom Index” domains (BASC). |
| 287 M, 247 F |
|
| DeRouen et al., 2006 [32] | RCT | 7 years | Portugal | 507 | 10.1 years | Dental amalgam; composite resin | Posterior teeth | Urinary Hg;
Urinary Albumin | Attention/concentration | NA | NA | Urinary Hg was significantly higher level in the amalgam group; no significant differences for other outcomes. |
| 279 M, 228 F | Memory |
| | Motor/visuomotor |
|
| Halbach et al., 2007 [33] | RCT | 1.5 years | Germany | 164 | NR | Dental amalgam; composite resin | NR | Urinary Hg | NA | NA | Total, organic, and inorganic Hg in plasma and red cells | No statistically significant differences were found in any outcome. |
| NR |
|
| Lauterbach et al., 2008 [34] | RCT | 7 years | Portugal | 507 | 10.1 years | Dental amalgam; composite resin | Posterior teeth | NA | NHSs, NSSs, and positional tremor | NA | NA | Statistically significant higher rate of NSSs was found in the composite resin group at the second time point. |
| 279 M, 228 F |
|
| Shenker et al., 2008 [36] | RCT | 5 years | USA | 534 | 7.9 years | Dispersed phase amalgam; composite resin | Posterior teeth | NA | NA | NA | WBC, T-cell, B-cell, and neutrophil and monocyte responsiveness | No statistically significant differences were found in any outcome. |
| 287 M, 247 F |
|
