Research Article

Effect of Methotrexate Injection on Orthodontic Tooth Movement: An Experimental Study on Rats

Table 1

Mean and standard deviation of orthodontic tooth movement (mm) in the four groups.

GroupsDistance of orthodontic tooth movement (OTM) at the beginning of the study (mm)Distance of orthodontic tooth movement (OTM) at the end of 21 days (mm)Differences between the beginning of the study and the end of the study (mm)
MeanSDMeanSDMean

Negative control0.200.020.220.020.02a
Positive control0.250.010.440.030.19b
Methotrexate 0.75 mg/kg0.200.010.510.0330.31b
Methotrexate 1.5 mg/kg0.220.030.780.0990.56d

Welch one-way ANOVA test followed by Tukey’s test was used. Means with same superscript letters are not significantly different (). SD: standard deviation.